Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8166794 | 0.92 | ADRA1D (0.57) | ADRA1DADRA1AADRA1BHDAC6LMNA | |
| SCHEMBL8174265 | 0.85 | HCRTR2 (0.42) | HCRTR2HTR2BLMNAKDM1AHCRTR1 | |
| SCHEMBL8175103 | 0.81 | TRPC3 (0.49) | ADRA1DADRA1AADRA1BCYP2C9 | |
| SCHEMBL8173512 | 0.81 | HTR2B (0.46) | HCRTR2HTR2BLMNAKDM1AHCRTR1 | |
| SCHEMBL8180362 | 0.80 | ADRA1D (0.44) | ADRA1DADRA1AADRA1BHCRTR2KDM1A | |
| SCHEMBL8174233 | 0.79 | ADRA1D (0.45) | ADRA1DADRA1AADRA1BHCRTR2HTR2B | |
| SCHEMBL8166223 | 0.77 | ADRA1D (0.47) | ADRA1DADRA1AADRA1BHCRTR2LMNA | |
| SCHEMBL8174942 | 0.75 | ADRA1D (0.45) | ADRA1DADRA1AADRA1BCYP2C9 | |
| SCHEMBL8174185 | 0.75 | LMNA (0.45) | ADRA1DADRA1AADRA1BHTR2BHDAC3 | |
| SCHEMBL8166964 | 0.75 | ADRA1D (0.59) | ADRA1DADRA1AADRA1BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6090825-A | Oxazole derivatives as antagonists of alpha 1C andrenergic receptors | GLAXO WELLCOME INC. (US) | 2000-07-18 | — | — | US | disclosed |