Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | RARA | P10276 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | RARG | P13631 | 1/20 | 0.39 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | PTPRF | P10586 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8176370 | 0.93 | CYP4A11 (0.44) | EGFRRARARARBRARGPTPRC | |
| SCHEMBL8176681 | 0.92 | CYP4A11 (0.41) | EGFRRARARARBRARGPTPRC | |
| SCHEMBL8175916 | 0.91 | EGFR (0.46) | EGFRPTPRCPTPRFPTPN1CDC25B | |
| SCHEMBL8180152 | 0.90 | CA1 (0.46) | EGFRPTPRCPTPRFPTPN1CDC25B | |
| SCHEMBL8167327 | 0.90 | TDP1 (0.46) | EGFRRARARARBRARGPTPRC | |
| SCHEMBL8167359 | 0.89 | CA1 (0.47) | EGFRPTPRCPTPRFPTPN1CDC25B | |
| SCHEMBL8166934 | 0.89 | SLC6A4 (0.48) | EGFRPTPRCPTPRFPTPN1CDC25B | |
| SCHEMBL8175144 | 0.89 | SLC6A4 (0.48) | EGFRPTPRCPTPRFPTPN1CDC25B | |
| SCHEMBL8176971 | 0.87 | MAPT (0.43) | EGFRPTPRCPTPRFPTPN1CDC25B | |
| SCHEMBL8181712 | 0.87 | EGFR (0.39) | EGFRPTPRCPTPRFPTPN1CDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6150413-A | TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, BONE AND OPHTHALMOLOGICAL DISORDERS, AS WELL AS MAMMALIAN SKIN AND HAIR CONDITIONS; 4-(4-(BIPHENYL-2-YL)BUT-3-EN-1-YNYL)BENZOIC ACID, FOR EXAMPLE | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 2000-11-21 | — | — | US | disclosed |