SCHEMBL8181712

SCHEMBL8181712

C=Cc1ccc(-c2ccccc2/C=C/C#Cc2ccc(C(=O)OC)cc2)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 1/20 0.39
PTPN1 P18031 3/20 0.37
ALDH1A1 P00352 3/20 0.37
PTPRC P08575 1/20 0.37
PTPRF P10586 1/20 0.37
CDC25B P30305 1/20 0.37
PTPN11 Q06124 1/20 0.36
TSHR P16473 2/20 0.35
KDM4E B2RXH2 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C9 P11712 1/20 0.35
HPGD P15428 1/20 0.35
CYP2C19 P33261 1/20 0.35
HSD17B10 Q99714 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
ALDH1A2 O94788 1/20 0.35
ALDH1A3 P47895 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
CA1 P00915 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8175916 0.89 EGFR (0.46) EGFRPTPN1ALDH1A1PTPRCPTPRF
SCHEMBL8180152 0.88 CA1 (0.46) EGFRPTPN1ALDH1A1PTPRCPTPRF
SCHEMBL8167327 0.88 TDP1 (0.46) EGFRPTPN1ALDH1A1PTPRCPTPRF
SCHEMBL8166934 0.87 SLC6A4 (0.48) EGFRPTPN1ALDH1A1PTPRCPTPRF
SCHEMBL8175144 0.87 SLC6A4 (0.48) EGFRPTPN1ALDH1A1PTPRCPTPRF
SCHEMBL8167359 0.87 CA1 (0.47) EGFRPTPN1PTPRCPTPRFCDC25B
SCHEMBL8175487 0.87 EGFR (0.40) EGFRPTPN1PTPRCPTPRFCDC25B
SCHEMBL7929260 0.87 RARB (0.40) ALDH1A1CYP1A2CYP2C9BACE1
SCHEMBL8181739 0.85 RAF1 (0.40) EGFRPTPN1ALDH1A1PTPRCPTPRF
SCHEMBL8176370 0.84 CYP4A11 (0.44) EGFRPTPN1PTPRCPTPRFCDC25B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6150413-A TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, BONE AND OPHTHALMOLOGICAL DISORDERS, AS WELL AS MAMMALIAN SKIN AND HAIR CONDITIONS; 4-(4-(BIPHENYL-2-YL)BUT-3-EN-1-YNYL)BENZOIC ACID, FOR EXAMPLE CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) 2000-11-21 US disclosed