Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | RBP4 | P02753 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18377475 | 0.82 | KLKB1 (0.56) | KLKB1RIPK1USP30RBP4 | |
| SCHEMBL15965171 | 0.79 | KLKB1 (0.47) | KLKB1RBP4 | |
| SCHEMBL24094049 | 0.79 | KLKB1 (0.55) | KLKB1RIPK1USP30RBP4 | |
| SCHEMBL23432082 | 0.79 | KLKB1 (0.53) | MEN1KMT2AKLKB1RIPK1USP30 | |
| SCHEMBL19304343 | 0.78 | ALDH1A1 (0.53) | MAPTMEN1KMT2A | |
| SCHEMBL31073512 | 0.78 | MEN1 (0.56) | MAPTMEN1KMT2AHPGDKLKB1 | |
| SCHEMBL16690901 | 0.78 | RBP4 (0.54) | NPC1RAB9ASMN1; SMN2KLKB1RIPK1 | |
| SCHEMBL3688462 | 0.77 | KDM4C (0.57) | NPC1RAB9AKLKB1RIPK1USP30 | |
| SCHEMBL18367381 | 0.77 | CDK5 (0.53) | SMN1; SMN2MEN1KMT2AKLKB1RIPK1 | |
| SCHEMBL24310642 | 0.75 | KDM4C (0.52) | NPC1RAB9AKLKB1RIPK1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |