Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 8/20 | 0.45 |
| ▸ | TCF7L2 | Q9NQB0 | 8/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8184062 | 0.93 | CYP1A2 (0.50) | PTGS2MAPTLMNAMEN1KMT2A | |
| SCHEMBL8178620 | 0.89 | LMNA (0.47) | CTNNB1TCF7L2PTGS2MAPTLMNA | |
| SCHEMBL8169994 | 0.89 | MEN1 (0.50) | MAPTLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8185475 | 0.89 | USP1 (0.44) | CTNNB1TCF7L2MAPTLMNAKMT2A | |
| SCHEMBL8178012 | 0.88 | PRKCI (0.49) | CTNNB1TCF7L2PTGS2MAPTLMNA | |
| SCHEMBL8182005 | 0.87 | FLT3 (0.49) | CTNNB1TCF7L2PTGS2MAPTLMNA | |
| SCHEMBL8183034 | 0.87 | PDE5A (0.45) | MEN1KMT2A | |
| SCHEMBL8179531 | 0.87 | CTNNB1 (0.47) | CTNNB1TCF7L2PTGS2MAPTLMNA | |
| SCHEMBL8181036 | 0.86 | USP1 (0.47) | MAPTLMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL8179520 | 0.84 | PDE5A (0.52) | MAPTLMNAMEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |