Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.77 |
| ▸ | LMNA | P02545 | 4/20 | 0.77 |
| ▸ | TSHR | P16473 | 3/20 | 0.77 |
| ▸ | HPGD | P15428 | 3/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.77 |
| ▸ | POLB | P06746 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30620393 | 0.85 | ALDH1A1 (0.56) | ALDH1A1LMNATSHRHPGDSMN1; SMN2 | |
| SCHEMBL22010011 | 0.84 | HPGD (0.67) | ALDH1A1LMNATSHRHPGDSMN1; SMN2 | |
| SCHEMBL11749337 | 0.82 | ALDH1A1 (0.61) | ALDH1A1LMNATSHRHPGDSMN1; SMN2 | |
| SCHEMBL16472210 | 0.82 | ALDH1A1 (0.71) | ALDH1A1LMNATSHRHPGDSMN1; SMN2 | |
| SCHEMBL10448232 | 0.79 | ALDH1A1 (1.00) | ALDH1A1LMNATSHRHPGDSMN1; SMN2 | |
| SCHEMBL10973042 | 0.79 | ALDH1A1 (0.71) | ALDH1A1LMNATSHRHPGDSMN1; SMN2 | |
| SCHEMBL10970208 | 0.79 | ALDH1A1 (0.71) | ALDH1A1LMNATSHRHPGDSMN1; SMN2 | |
| SCHEMBL9137875 | 0.79 | ALDH1A1 (0.71) | ALDH1A1LMNATSHRHPGDSMN1; SMN2 | |
| SCHEMBL5815122 | 0.78 | ALDH1A1 (0.65) | ALDH1A1LMNATSHRHPGDSMN1; SMN2 | |
| SCHEMBL1610031 | 0.78 | POLB (1.00) | ALDH1A1LMNATSHRHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008118626-A9 | INHIBITORS OF JNK AND METHODS FOR IDENTIFYING INHIBITORS OF JNK | BURNHAM INST MEDICAL RESEARCH (US) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008118626-A2 | INHIBITORS OF JNK AND METHODS FOR IDENTIFYING INHIBITORS OF JNK | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2008-10-02 | — | — | WO | disclosed |