Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | CA12 | O43570 | 3/20 | 0.53 |
| ▸ | CA1 | P00915 | 3/20 | 0.53 |
| ▸ | CA2 | P00918 | 3/20 | 0.53 |
| ▸ | CA7 | P43166 | 3/20 | 0.53 |
| ▸ | CA9 | Q16790 | 3/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | CDC25B | P30305 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | F2R | P25116 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10571657 | 0.87 | TSHR (0.73) | TSHRCA12CA1CA2CA7 | |
| SCHEMBL265052 | 0.84 | TSHR (0.63) | TSHRCA12CA1CA2CA7 | |
| SCHEMBL1980259 | 0.84 | TSHR (0.53) | TSHRCA12CA1CA2CA7 | |
| SCHEMBL27268560 | 0.84 | TSHR (0.66) | TSHRALDH1A1HSD17B10CYP1A2KDM4E | |
| SCHEMBL408906 | 0.84 | TSHR (0.74) | TSHRALDH1A1HSD17B10RXFP1GAA | |
| SCHEMBL4626397 | 0.83 | TSHR (0.61) | TSHRCA12CA1CA2CA7 | |
| SCHEMBL1242911 | 0.82 | GAA (0.66) | TSHRCA12CA1CA2CA7 | |
| Bromide SCHEMBL15544606 | 0.82 | TSHR (0.71) | TSHRALDH1A1HSD17B10RXFP1GAA | |
| SCHEMBL340364 | 0.82 | CA12 (0.67) | TSHRCA12CA1CA2CA7 | |
| SCHEMBL28628629 | 0.82 | TSHR (0.71) | TSHRALDH1A1HSD17B10RXFP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000078726-A1 | IMIDAZOLINE DERIVATIVES FOR THE TREATMENT OF DIABETES, ESPECIALLY TYPE II DIABETES | ELI LILLY AND COMPANY (US) | 2000-12-28 | — | — | WO | disclosed |