Sugi Predict

Sugi Predict / Compounds / SCHEMBL1980259

SCHEMBL1980259

SCHEMBL1980259

CCOC(=O)c1ccc(Br)c(O)c1O

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 2/20 0.53
▸ CA12 O43570 5/20 0.53
▸ CA1 P00915 5/20 0.53
▸ CA2 P00918 5/20 0.53
▸ CA7 P43166 5/20 0.53
▸ CA9 Q16790 5/20 0.53
▸ CA14 Q9ULX7 5/20 0.53
▸ MAPT P10636 5/20 0.50
▸ GAA P10253 3/20 0.50
▸ MEN1 O00255 2/20 0.50
▸ KMT2A Q03164 2/20 0.50
▸ ALOX15 P16050 1/20 0.50
▸ ALDH1A1 P00352 3/20 0.46
▸ HSD17B10 Q99714 1/20 0.46
▸ SMN1; SMN2 Q16637 1/20 0.46
▸ ESR1 P03372 1/20 0.46
▸ ESR2 Q92731 1/20 0.46
▸ PKM P14618 2/20 0.44
▸ KDM4E B2RXH2 2/20 0.44
▸ TLR2 O60603 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4262832 0.89 TSHR (0.65) TSHRCA12CA1CA2CA7
SCHEMBL30960327 0.89 TSHR (0.65) TSHRCA12CA1CA2CA7
SCHEMBL9303395 0.88 TSHR (0.52) TSHRCA12CA1CA2CA7
SCHEMBL2903968 0.88 TSHR (0.52) TSHRCA12CA1CA2CA7
SCHEMBL21487957 0.85 MEN1 (0.53) TSHRCA12CA1CA2CA7
SCHEMBL8178343 0.84 TSHR (0.61) TSHRCA12CA1CA2CA7
SCHEMBL6233355 0.83 ESR1 (0.59) TSHRALDH1A1HSD17B10SMN1; SMN2ESR1
SCHEMBL639072 0.81 ALDH1A1 (0.61) TSHRCA12CA1CA2CA7
SCHEMBL3173907 0.81 TSHR (0.57) TSHRCA12CA1CA2CA7
SCHEMBL15746273 0.81 TSHR (0.57) TSHRCA12CA1CA2CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260146037-A1 PEPTIDYL NITRILE COMPOUND AND USE THEREOF SHANGHAI YIDIAN PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD (CN) 2026-05-28 — — US disclosed
EP-4748839-A1 POLYCYCLIC COMPOUND AND USE THEREOF CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. (CN) 2026-05-27 — — EP disclosed
US-20250101011-A1 PEPTIDYL NITRILE COMPOUND AND USE THEREOF SHANGHAI YIDIAN PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD (CN) 2025-03-27 — — US disclosed
WO-2025021048-A1 POLYCYCLIC COMPOUND AND USE THEREOF 石药集团中奇制药技术（石家庄）有限公司 2025-01-30 — — WO disclosed
CN-119330949-A Polycyclic compound and application thereof 石药集团中奇制药技术（石家庄）有限公司 2025-01-21 — — CN disclosed
EP-4450497-A1 PEPTIDYL NITRILE COMPOUND AND USE THEREOF Shanghai Yidian Pharmaceutical Technology Development Co., Ltd (CN) 2024-10-23 — — EP disclosed
CN-112996786-B Compounds for inhibiting alpha 4 beta 7 integrin 吉利德科学公司 2024-08-20 — — CN disclosed
CN-118475575-A Peptidyl nitrile compound and application thereof 上海壹典医药科技开发有限公司 2024-08-09 — — CN disclosed
US-20230398225-A1 PD-L1/STING CONJUGATES AND METHODS OF USE INCYTE CORPORATION 2023-12-14 — — US disclosed
WO-2023134656-A1 PEPTIDYL NITRILE COMPOUND AND USE THEREOF 上海壹典医药科技开发有限公司 2023-07-20 — — WO disclosed
US-20210163493-A1 HETEROARYL AMIDE COMPOUNDS AS STING ACTIVATORS INCYTE CORPORATION 2021-06-03 — — US disclosed
US-10875872-B2 Heteroaryl amide compounds as sting activators INCYTE CORPORATION (US) 2020-12-29 — — US disclosed
US-20200155563-A1 COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN GILEAD SCIENCES, INC. 2020-05-21 — — US disclosed
US-20200039994-A1 HETEROARYL AMIDE COMPOUNDS AS STING ACTIVATORS INCYTE CORPORATION 2020-02-06 — — US disclosed
WO-2020028566-A1 HETEROARYL AMIDE COMPOUNDS AS STING ACTIVATORS INCYTE CORPORATION (US) 2020-02-06 — — WO disclosed
WO-2011075607-A1 NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION INTERMUNE, INC. (US) 2011-06-23 — — WO disclosed
WO-2011075607-A1 NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION INTERMUNE, INC. (US) 2011-06-23 — — WO disclosed
US-20110152246-A1 NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION INTERMUNE, INC. (US) 2011-06-23 — — US disclosed
US-20110152246-A1 NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION INTERMUNE, INC. (US) 2011-06-23 — — US disclosed
US-20110152246-A1 NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION INTERMUNE, INC. (US) 2011-06-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250101011-A1 PEPTIDYL NITRILE COMPOUND AND USE THEREOF CTSC, CTSL, CTRL TSHR 3974/4885CA12 1354/4885CA1 714/4885
US-20110152246-A1 NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION EIF2AK2, HAVCR2, IRF3 TSHR 4747/4885CA12 4538/4885CA1 4777/4885
US-20200155563-A1 COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN ITGB7, ITGB4, ITGA4 TSHR 3863/4885CA12 2740/4885CA1 2759/4885
US-20230398225-A1 PD-L1/STING CONJUGATES AND METHODS OF USE STING1, PDCD1LG2, CD274 TSHR 1533/4885CA12 3397/4885CA1 4488/4885
US-10875872-B2 Heteroaryl amide compounds as sting activators STING1, MAVS, IRF3 TSHR 3601/4885CA12 4862/4885CA1 4884/4885
US-20210163493-A1 HETEROARYL AMIDE COMPOUNDS AS STING ACTIVATORS STING1, MAVS, IRF3 TSHR 3601/4885CA12 4862/4885CA1 4884/4885
US-20260146037-A1 PEPTIDYL NITRILE COMPOUND AND USE THEREOF JAK1, CTSZ, CTSL TSHR 1163/4885CA12 1004/4885CA1 786/4885
US-20200039994-A1 HETEROARYL AMIDE COMPOUNDS AS STING ACTIVATORS STING1, MAVS, IRF3 TSHR 3601/4885CA12 4862/4885CA1 4884/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.