Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.55 |
| ▸ | PRKCI | P41743 | 13/20 | 0.49 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8185547 | 0.90 | PTGS2 (0.51) | PTGS2PRKCIMEN1MAPTKMT2A | |
| SCHEMBL7015020 | 0.90 | PTGS2 (0.51) | PTGS2PRKCIPRKCZMEN1MAPT | |
| SCHEMBL8179988 | 0.88 | PTGS2 (0.65) | PTGS2PRKCIPRKCZKDM4EMEN1 | |
| SCHEMBL8169588 | 0.87 | PRKCI (0.59) | PTGS2PRKCIPRKCZKDM4EMEN1 | |
| SCHEMBL5782433 | 0.87 | PRKCI (0.66) | PRKCIPRKCZ | |
| SCHEMBL7015745 | 0.85 | PTGS2 (0.53) | PTGS2PRKCIPRKCZKDM4EMEN1 | |
| SCHEMBL8178943 | 0.85 | PTGS2 (0.53) | PTGS2PRKCIPRKCZMEN1MAPT | |
| SCHEMBL8172960 | 0.83 | LMNA (0.49) | PTGS2PRKCIMAPT | |
| SCHEMBL8186250 | 0.82 | FYN (0.46) | PRKCIKDM4EMEN1NPC1MAPT | |
| SCHEMBL8180806 | 0.82 | FYN (0.46) | PRKCIKDM4EMEN1NPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |