Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.51 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.51 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | PRKCI | P41743 | 14/20 | 0.47 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6709545 | 0.92 | PTGS2 (0.52) | PTGS2PTPN12PTPN22PRKCIPRKCZ | |
| SCHEMBL8185252 | 0.92 | PTGS2 (0.51) | PTGS2PTPN12PTPN22PRKCIPRKCZ | |
| SCHEMBL8182054 | 0.91 | PTGS2 (0.53) | PTGS2PTPN12PTPN22PDE5APRKCI | |
| SCHEMBL8178899 | 0.91 | PTPN12 (0.49) | PTGS2PTPN12PTPN22PRKCI | |
| SCHEMBL7408485 | 0.88 | PRKCI (0.62) | PRKCIPRKCZ | |
| SCHEMBL8182385 | 0.86 | PTGS2 (0.51) | PTGS2PRKCIPRKCZKDM4EMEN1 | |
| SCHEMBL8179988 | 0.85 | PTGS2 (0.65) | PTGS2PDE5APRKCIPRKCZKDM4E | |
| SCHEMBL8178683 | 0.85 | PTGS2 (0.55) | PTGS2PRKCIPRKCZKDM4EMEN1 | |
| SCHEMBL8169588 | 0.85 | PRKCI (0.59) | PTGS2PRKCIPRKCZKDM4EMEN1 | |
| SCHEMBL7010123 | 0.84 | PDE5A (0.49) | PDE5APRKCIMEN1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | claimed |
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | claimed |
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |