Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | GRK5 | P34947 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7931850 | 0.73 | NFE2L2 (0.37) | CHEK1AURKADAPK3JAK2ABL1 | |
| SCHEMBL7931856 | 0.73 | NFE2L2 (0.37) | CHEK1AURKADAPK3JAK2ABL1 | |
| SCHEMBL7935210 | 0.72 | SMN1; SMN2 (0.40) | CHEK1AURKADAPK3JAK2ABL1 | |
| SCHEMBL8167944 | 0.70 | FYN (0.39) | FYNSMN1; SMN2HPGDKMT2AEGFR | |
| SCHEMBL1607613 | 0.69 | EGFR (0.44) | CHEK1AURKADAPK3JAK2ABL1 | |
| SCHEMBL6934710 | 0.67 | SYK (0.48) | CHEK1AURKADAPK3JAK2ABL1 | |
| SCHEMBL9325967 | 0.67 | MAPT (0.50) | L3MBTL1SMN1; SMN2LMNAHPGDHTT | |
| SCHEMBL7643473 | 0.66 | LMNA (0.42) | PTPN1L3MBTL1SMN1; SMN2LMNAHPGD | |
| SCHEMBL2047965 | 0.65 | LMNA (0.38) | PTPN1SMN1; SMN2LMNAHPGDHTT | |
| SCHEMBL4988220 | 0.65 | FABP3 (0.57) | ATML3MBTL1SMN1; SMN2HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6150413-A | TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, BONE AND OPHTHALMOLOGICAL DISORDERS, AS WELL AS MAMMALIAN SKIN AND HAIR CONDITIONS; 4-(4-(BIPHENYL-2-YL)BUT-3-EN-1-YNYL)BENZOIC ACID, FOR EXAMPLE | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 2000-11-21 | — | — | US | disclosed |