Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CCR5 | P51681 | 1/20 | 0.48 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 3/20 | 0.37 |
| ▸ | NOS1 | P29475 | 3/20 | 0.37 |
| ▸ | NOS2 | P35228 | 3/20 | 0.37 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9015132 | 0.71 | CYP1A2 (0.46) | NOS3NOS1NOS2 | |
| SCHEMBL25312907 | 0.69 | METAP2 (0.47) | CCR1RAB9ACCR5METAP2PARP1 | |
| Neocuproine SCHEMBL124563 | 0.68 | CCR1 (1.00) | CCR1RAB9ACCR5METAP2PARP1 | |
| Neocuproine SCHEMBL11672280 | 0.68 | CCR1 (1.00) | CCR1RAB9ACCR5METAP2PARP1 | |
| Neocuproine SCHEMBL29367091 | 0.68 | CCR1 (1.00) | CCR1RAB9ACCR5METAP2PARP1 | |
| Neocuproine SCHEMBL29639703 | 0.68 | CCR1 (1.00) | CCR1RAB9ACCR5METAP2PARP1 | |
| SCHEMBL13740154 | 0.68 | CCR1 (0.48) | CCR1RAB9ACCR5METAP2PARP1 | |
| Neocuproine SCHEMBL17926728 | 0.66 | CCR1 (0.94) | CCR1RAB9ACCR5METAP2PARP1 | |
| Neocuproine SCHEMBL5385744 | 0.66 | CCR1 (0.94) | CCR1RAB9ACCR5METAP2PARP1 | |
| Neocuproine SCHEMBL1462062 | 0.66 | CCR1 (0.94) | CCR1RAB9ACCR5METAP2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0643045-B1 | Quinoline derivatives as leukotriene antagonists | NOVARTIS AG (CH) | 2000-03-08 | — | — | EP | disclosed |
| EP-0643045-A1 | Quinoline derivatives as leukoriene antagonists | CIBA-GEIGY AG (CH) | 1995-03-15 | — | — | EP | disclosed |