Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6380225 | 0.84 | PKM (0.37) | LMNAHTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL1124105 | 0.78 | TDP1 (0.35) | TDP1 | |
| SCHEMBL9538834 | 0.77 | CYP1A2 (0.53) | LMNAHTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL11916226 | 0.77 | CYP2C19 (0.42) | LMNAHTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL12475927 | 0.74 | LMNA (0.41) | LMNAHTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL8721097 | 0.74 | CCNA2 (0.33) | LMNAPKMRXFP1 | |
| SCHEMBL16016862 | 0.74 | LMNA (0.41) | LMNAHTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL26287666 | 0.74 | CYP1A2 (0.43) | LMNAHTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL8870129 | 0.72 | TDP1 (0.31) | TDP1 | |
| SCHEMBL22119996 | 0.71 | LMNA (0.39) | LMNAHTR1AADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000046212-A1 | METHOD OF PRODUCING SUBSTITUTED PYRIMIDINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2000-08-10 | — | — | WO | claimed |
| WO-2000046212-A1 | METHOD OF PRODUCING SUBSTITUTED PYRIMIDINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2000-08-10 | — | — | WO | disclosed |