Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8721097 | 0.84 | CCNA2 (0.33) | PKMRXFP1DYRK1ALMNA | |
| SCHEMBL8182248 | 0.84 | LMNA (0.41) | PKMRXFP1LMNAHTR1AADRA2A | |
| SCHEMBL12936233 | 0.72 | PKM (0.37) | PKMRXFP1DYRK1ALMNAHTR1A | |
| SCHEMBL3674088 | 0.72 | PKM (0.37) | PKMRXFP1DYRK1ALMNAHTR1A | |
| SCHEMBL6333400 | 0.72 | ALDH1A1 (0.41) | PKMRXFP1DYRK1ALMNAHTR1A | |
| SCHEMBL12649521 | 0.72 | DYRK1A (0.39) | PKMRXFP1DYRK1ALMNAHTR1A | |
| SCHEMBL9666350 | 0.70 | — | — | |
| SCHEMBL19674748 | 0.70 | PKM (0.36) | PKMRXFP1DYRK1ALMNAHTR1A | |
| SCHEMBL10734347 | 0.67 | PKM (0.38) | PKMRXFP1DYRK1A | |
| SCHEMBL13752394 | 0.67 | CCNA2 (0.53) | PKMRXFP1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165524-B1 | METHOD OF PRODUCING THIOBARBITURIC ACID DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2005-06-01 | — | — | EP | claimed |
| US-6673925-B2 | REACTING BIS(4,6-DICHLORO-2-PYRIMIDINE)DISULFIDE WITH HYDROGENOLYSIS AGENT IN THE PRESENCE OF AN INERT SOLVENT AND REACTING HYDROGENOLYSIS PRODUCT WITH ALKALI METAL METHYLATE IN METHANOL | SYNGENTA CROP PROTECTION, INC. | 2004-01-06 | — | — | US | claimed |
| US-20020095037-A1 | Method of producing thiobarbituric acid derivatives | SYNGENTA CROP PROTECTION, INC. | 2002-07-18 | — | — | US | claimed |
| EP-1165524-A2 | METHOD OF PRODUCING THIOBARBITURIC ACID DERIVATIVES | Syngenta Participations AG (CH) | 2002-01-02 | — | — | EP | claimed |
| WO-2000046213-A2 | METHOD OF PRODUCING THIOBARBITURIC ACID DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2000-08-10 | — | — | WO | claimed |
| CN-219765299-U | Synthesis system of chemical intermediate | 宁夏润泽欣邦化工有限公司 | 2023-09-29 | — | — | CN | disclosed |
| EP-1165524-B1 | METHOD OF PRODUCING THIOBARBITURIC ACID DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2005-06-01 | — | — | EP | disclosed |
| US-6673925-B2 | REACTING BIS(4,6-DICHLORO-2-PYRIMIDINE)DISULFIDE WITH HYDROGENOLYSIS AGENT IN THE PRESENCE OF AN INERT SOLVENT AND REACTING HYDROGENOLYSIS PRODUCT WITH ALKALI METAL METHYLATE IN METHANOL | SYNGENTA CROP PROTECTION, INC. | 2004-01-06 | — | — | US | disclosed |
| US-20020095037-A1 | Method of producing thiobarbituric acid derivatives | SYNGENTA CROP PROTECTION, INC. | 2002-07-18 | — | — | US | disclosed |
| EP-1165524-A2 | METHOD OF PRODUCING THIOBARBITURIC ACID DERIVATIVES | Syngenta Participations AG (CH) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000046213-A2 | METHOD OF PRODUCING THIOBARBITURIC ACID DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2000-08-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020095037-A1 | Method of producing thiobarbituric acid derivatives | BHMT2, MGMT, MRM1 | PKM 759/4885RXFP1 4565/4885DYRK1A 4332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.