Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 10/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.62 |
| ▸ | POLB | P06746 | 9/20 | 0.62 |
| ▸ | MAPT | P10636 | 7/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.58 |
| ▸ | HPGD | P15428 | 5/20 | 0.58 |
| ▸ | BLM | P54132 | 4/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.58 |
| ▸ | PIM1 | P11309 | 5/20 | 0.57 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13567557 | 1.00 | MEN1 (0.62) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL462449 | 1.00 | MEN1 (0.62) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL624098 | 0.84 | MEN1 (0.55) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL624099 | 0.84 | MEN1 (0.55) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL5139092 | 0.84 | MEN1 (0.59) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL5139089 | 0.84 | MEN1 (0.59) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL5139091 | 0.84 | MEN1 (0.59) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL6782912 | 0.74 | HPGD (0.50) | MEN1KMT2APOLBHPGDRAB9A | |
| SCHEMBL211085 | 0.73 | PIM1 (1.00) | HPGDRAB9ATDP1PIM1PIM2 | |
| SCHEMBL1250387 | 0.73 | PIM1 (1.00) | HPGDRAB9ATDP1PIM1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240034799-A1 | METHODS AND SYSTEMS OF STRATIFYING INFLAMMATORY DISEASE PATIENTS | CEDARS SINAI MEDICAL CENTER (US) | 2024-02-01 | — | — | US | disclosed |
| US-20230279491-A1 | TREATMENTS FOR A SUB-POPULATION OF INFLAMMATORY BOWEL DISEASE PATIENTS | CEDARS-SINAI MEDICAL CENTER | 2023-09-07 | — | — | US | disclosed |
| US-20230105307-A1 | Identification of Stabilizers of Multimeric Proteins | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2023-04-06 | — | — | US | disclosed |
| US-11337935-B2 | Identification of stabilizers of multimeric proteins | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2022-05-24 | — | — | US | disclosed |
| US-20200016098-A1 | Identification of Stabilizers of Multimeric Proteins | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2020-01-16 | — | — | US | disclosed |
| US-10278929-B2 | Identification of stabilizers of multimeric proteins | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2019-05-07 | — | — | US | disclosed |
| US-20190054040-A1 | Identification of Stabilizers of Multimeric Proteins | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2019-02-21 | — | — | US | disclosed |
| US-10039726-B2 | Identification of stabilizers of multimeric proteins | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2018-08-07 | — | — | US | disclosed |
| WO-2000018746-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230105307-A1 | Identification of Stabilizers of Multimeric Proteins | TTR, HSPBP1, HSPH1 | MEN1 3230/4885KMT2A 4530/4885POLB 4674/4885 |
| US-20190054040-A1 | Identification of Stabilizers of Multimeric Proteins | TTR, HSPBP1, HSPH1 | MEN1 3230/4885KMT2A 4530/4885POLB 4674/4885 |
| US-10278929-B2 | Identification of stabilizers of multimeric proteins | TTR, HSPBP1, HSPH1 | MEN1 3432/4885KMT2A 4604/4885POLB 4603/4885 |
| US-11337935-B2 | Identification of stabilizers of multimeric proteins | TTR, HSPBP1, HSPH1 | MEN1 3230/4885KMT2A 4530/4885POLB 4674/4885 |
| US-10039726-B2 | Identification of stabilizers of multimeric proteins | TTR, ALB, HSPBP1 | MEN1 3671/4885KMT2A 4735/4885POLB 3739/4885 |
| US-20200016098-A1 | Identification of Stabilizers of Multimeric Proteins | TTR, HSPBP1, HSPH1 | MEN1 3230/4885KMT2A 4530/4885POLB 4674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.