SCHEMBL8183302

SCHEMBL8183302

COCOc1ccc(C=O)c(OS(=O)(=O)C(F)(F)F)c1

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.43
CA1 P00915 2/20 0.38
CA2 P00918 2/20 0.38
MAOB P27338 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.35
HTR1D P28221 5/20 0.35
HTR1A P08908 4/20 0.35
HTR1B P28222 4/20 0.35
TUBB1 Q9H4B7 1/20 0.34
POLB P06746 1/20 0.34
MAPT P10636 1/20 0.34
HSD11B1 P28845 1/20 0.34
DRD2 P14416 1/20 0.34
DRD3 P35462 1/20 0.34
TRIM24 O15164 1/20 0.33
TYR P14679 1/20 0.33
TRIM33 Q9UPN9 1/20 0.33
CYP1A1 P04798 1/20 0.33
CYP1B1 Q16678 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8180028 0.90 TUBB1 (0.42) ALDH1A1CA1CA2HTR1DHTR1A
SCHEMBL710706 0.85 ALDH1A1 (0.61) ALDH1A1CA1CA2L3MBTL1MAPT
SCHEMBL29828482 0.85 ALDH1A1 (0.61) ALDH1A1CA1CA2L3MBTL1MAPT
SCHEMBL15188964 0.85 MAOB (0.41) ALDH1A1CA1CA2MAOBL3MBTL1
SCHEMBL2001499 0.84 ALDH1A1 (0.63) ALDH1A1CA1CA2L3MBTL1MAPT
SCHEMBL4974740 0.81 POLB (0.49) CA1CA2MAOBPOLBMAPT
SCHEMBL29456101 0.81 POLB (0.49) CA1CA2MAOBPOLBMAPT
SCHEMBL3200445 0.80 ALDH1A1 (0.56) ALDH1A1MAOBL3MBTL1TUBB1MAPT
SCHEMBL23043084 0.80 CXCR2 (0.36) CA1CA2L3MBTL1HTR1DHTR1A
SCHEMBL3905573 0.79 ALDH1A1 (0.69) ALDH1A1MAOBL3MBTL1TUBB1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6150413-A TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, BONE AND OPHTHALMOLOGICAL DISORDERS, AS WELL AS MAMMALIAN SKIN AND HAIR CONDITIONS; 4-(4-(BIPHENYL-2-YL)BUT-3-EN-1-YNYL)BENZOIC ACID, FOR EXAMPLE CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) 2000-11-21 US disclosed