Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.42 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.42 |
| ▸ | TYR | P14679 | 1/20 | 0.42 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 2/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3905573 | 0.92 | ALDH1A1 (0.69) | ALDH1A1MAOBTUBB1TRIM24TYR | |
| SCHEMBL3209556 | 0.92 | ALDH1A1 (0.69) | ALDH1A1HDAC8MAOBTRIM24TYR | |
| SCHEMBL15189007 | 0.89 | ALDH1A1 (0.49) | ALDH1A1HDAC8MAOBTUBB1L3MBTL1 | |
| SCHEMBL3211256 | 0.87 | ALDH1A1 (0.46) | ALDH1A1HDAC8MAOBTUBB1TRIM24 | |
| SCHEMBL19640030 | 0.87 | MAOB (0.48) | ALDH1A1HDAC8MAOBTUBB1TRIM24 | |
| SCHEMBL16705703 | 0.86 | TUBB1 (0.52) | ALDH1A1HDAC8TUBB1TRIM24TYR | |
| SCHEMBL4998794 | 0.86 | ALDH1A1 (0.49) | ALDH1A1HDAC8MAOBTUBB1TRIM24 | |
| SCHEMBL1445747 | 0.85 | MAOB (0.50) | ALDH1A1HDAC8MAOBTUBB1ERN1 | |
| SCHEMBL22090594 | 0.85 | HDAC8 (0.53) | ALDH1A1HDAC8TUBB1TRIM24TYR | |
| SCHEMBL1963431 | 0.85 | HDAC8 (0.52) | ALDH1A1HDAC8MAOBTUBB1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4698520-A1 | RAF-MEK PROTEIN COMPLEX MODULATORS AND METHODS OF USE THEREOF | Gandeeva Therapeutics, Inc. (US) | 2026-02-25 | — | — | EP | disclosed |
| WO-2024220708-A1 | RAF-MEK PROTEIN COMPLEX MODULATORS AND METHODS OF USE THEREOF | GANDEEVA THERAPEUTICS, INC. (US) | 2024-10-24 | — | — | WO | disclosed |
| CN-110483258-B | Diaryl derivative compound and skin whitening composition containing the same | 株式会社爱茉莉太平洋 | 2024-04-12 | — | — | CN | disclosed |
| CN-111184866-B | Combination treatment of bacterial infections | 香港中文大学 | 2023-12-19 | — | — | CN | disclosed |
| US-11690810-B2 | Combination treatment of bacterial infection | THE CHINESE UNIVERSITY OF HONG KONG (CN) | 2023-07-04 | — | — | US | disclosed |
| US-20200155641-A1 | COMBINATION TREATMENT OF BACTERIAL INFECTION | THE CHINESE UNIVERSITY OF HONG KONG (CN) | 2020-05-21 | — | — | US | disclosed |
| EP-2516414-B1 | HETEROAROMATIC COMPOUND, OPTICAL MATERIAL AND OPTICAL ELEMENT | CANON KK (JP) | 2017-08-02 | — | — | EP | disclosed |
| US-8962674-B2 | Curcumin derivative | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2015-02-24 | — | — | US | disclosed |
| US-20140315956-A1 | SMALL MOLECULE INHIBITORS OF IL-6 AND USES THEREOF | NATIONWIDE CHILDREN'S HOSPITAL (US) | 2014-10-23 | — | — | US | disclosed |
| US-20140315956-A1 | SMALL MOLECULE INHIBITORS OF IL-6 AND USES THEREOF | NATIONWIDE CHILDREN'S HOSPITAL (US) | 2014-10-23 | — | — | US | disclosed |
| US-20140315956-A1 | SMALL MOLECULE INHIBITORS OF IL-6 AND USES THEREOF | NATIONWIDE CHILDREN'S HOSPITAL (US) | 2014-10-23 | — | — | US | disclosed |
| US-8609869-B2 | Heteroaromatic-containing compound, optical material and optical element | CANON KABUSHIKI KAISHA (JP) | 2013-12-17 | — | — | US | disclosed |
| WO-2013019690-A1 | SMALL MOLECULE INHIBITORS OF IL-6 AND USES THEREOF | THE OHIO STATE UNIVERSITY (US) | 2013-02-07 | — | — | WO | disclosed |
| US-20120203012-A1 | HETEROAROMATIC-CONTAINING COMPOUND, OPTICAL MATERIAL AND OPTICAL ELEMENT | CANON KABUSHIKI KAISHA (JP) | 2012-08-09 | — | — | US | disclosed |
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2123637-A1 | NOVEL CURCUMIN DERIVATIVE | Tokyo Institute of Technology (JP) | 2009-11-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200155641-A1 | COMBINATION TREATMENT OF BACTERIAL INFECTION | PGC, NRDC, PYCARD | ALDH1A1 3345/4885HDAC8 241/4885MAOB 1068/4885 |
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | BACE1, APP, BACE2 | ALDH1A1 253/4885HDAC8 796/4885MAOB 969/4885 |
| US-20140315956-A1 | SMALL MOLECULE INHIBITORS OF IL-6 AND USES THEREOF | IL6, STAT3, JAK2 | ALDH1A1 1300/4885HDAC8 862/4885MAOB 2115/4885 |
| US-20120203012-A1 | HETEROAROMATIC-CONTAINING COMPOUND, OPTICAL MATERIAL AND OPTICAL ELEMENT | AR, AHR, ARNT | ALDH1A1 304/4885HDAC8 1941/4885MAOB 1327/4885 |
| US-11690810-B2 | Combination treatment of bacterial infection | PGC, NRDC, PYCARD | ALDH1A1 3345/4885HDAC8 241/4885MAOB 1068/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.