Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7792074 | 0.85 | ROCK2 (0.51) | ROCK2CYP3A4KMT2ANPC1RAB9A | |
| SCHEMBL6293939 | 0.85 | ROCK2 (0.65) | ROCK2CYP3A4ABCB1ABCG2KMT2A | |
| SCHEMBL8185594 | 0.85 | ALDH1A1 (0.59) | ROCK2CYP3A4KMT2ANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7792070 | 0.85 | NPC1 (0.59) | ROCK2CYP3A4KMT2ANPC1RAB9A | |
| SCHEMBL7849356 | 0.84 | ROCK2 (0.56) | ROCK2CYP3A4ABCB1ABCG2NPC1 | |
| SCHEMBL8184565 | 0.83 | KMT2A (0.58) | ROCK2CYP3A4KMT2ANPC1RAB9A | |
| SCHEMBL8130831 | 0.83 | ROCK2 (0.52) | ROCK2CYP3A4ABCB1ABCG2KMT2A | |
| SCHEMBL8188782 | 0.83 | ACHE (0.64) | ROCK2CYP3A4NPC1RAB9AMAPT | |
| SCHEMBL6293671 | 0.83 | F10 (0.48) | ROCK2CYP3A4ABCB1ABCG2NPC1 | |
| SCHEMBL8191620 | 0.83 | ROCK2 (0.54) | ROCK2CYP3A4KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6110934-A | Substituted benzamide derivatives and their use as anticonvulsants | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-08-29 | — | — | US | disclosed |
| EP-0906283-A1 | SUBSTITUTED BENZAMIDE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997048683-A1 | SUBSTITUTED BENZAMIDE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1997-12-24 | — | — | WO | disclosed |