Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.69 |
| ▸ | HPGD | P15428 | 2/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | RECQL | P46063 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.66 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | HTR7 | P34969 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.55 |
| ▸ | NAMPT | P43490 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8184631 | 1.00 | KDM4E (0.69) | KDM4EHSD17B10HPGDCYP3A4CYP2C9 | |
| SCHEMBL8184634 | 0.83 | KDM4E (0.65) | KDM4EHSD17B10HPGDCYP3A4CYP2C9 | |
| SCHEMBL8183959 | 0.82 | MAPT (0.66) | HSD17B10ALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8183961 | 0.82 | MAPT (0.66) | HSD17B10ALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL7362098 | 0.82 | KDM4E (1.00) | KDM4EHSD17B10HPGDCYP3A4CYP2C9 | |
| SCHEMBL9987671 | 0.79 | KDM4E (0.75) | KDM4EHSD17B10HPGDCYP3A4CYP2C9 | |
| SCHEMBL30206549 | 0.79 | KDM4E (0.75) | KDM4EHSD17B10HPGDCYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL4383380 | 0.78 | HSD17B10 (0.76) | KDM4EHSD17B10HPGDCYP3A4CYP2C9 | |
| SCHEMBL596065 | 0.77 | KDM4E (0.72) | KDM4EHSD17B10HPGDCYP3A4CYP2C9 | |
| SCHEMBL5052466 | 0.77 | KDM4E (0.72) | KDM4EHSD17B10HPGDCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6136781-A | NOVEL CYCLIC PENTAPEPTIDE OR SALTS EFFECTIVE AS MEDICINES FOR PREVENTING AND CURING SEX HORMONE-DEPENDENT CANCERS, PROSTATOMEGALY, ENDOMETRIOSIS, HYSTEROMYOMA, PUBERTY PRECOX, AMENORRHEAL SYNDROMES, MULTIOCULAR OVARIAN SYNDROMES, ALSO | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| CN-1183104-A | LH-RH receptor antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1998-05-27 | — | — | CN | disclosed |
| EP-0822939-A1 | CYCLIC PENTAPEPTIDE LH-RH RECEPTOR ANTAGONISTS | Takeda Chemical Industries, Ltd. (JP) | 1998-02-11 | — | — | EP | disclosed |
| WO-1996034012-A1 | CYCLIC PENTAPEPTIDE LH-RH RECEPTOR ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-10-31 | — | — | WO | disclosed |