Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | RECQL | P46063 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.62 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | KDM6B | O15054 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8184632 | 0.83 | KDM4E (0.69) | KDM4EHSD17B10CYP3A4CYP2C9HPGD | |
| SCHEMBL8184631 | 0.83 | KDM4E (0.69) | KDM4EHSD17B10CYP3A4CYP2C9HPGD | |
| SCHEMBL8183965 | 0.82 | MAPT (0.54) | CYP2C9ALDH1A1TSHRSMN1; SMN2MAPK1 | |
| SCHEMBL10858817 | 0.81 | ALDH1A1 (0.62) | KDM4EHSD17B10CYP3A4CYP2C9HPGD | |
| SCHEMBL10858811 | 0.81 | ALDH1A1 (0.62) | KDM4EHSD17B10CYP3A4CYP2C9HPGD | |
| SCHEMBL7362098 | 0.79 | KDM4E (1.00) | KDM4EHSD17B10CYP3A4CYP2C9HPGD | |
| SCHEMBL23717902 | 0.77 | ALDH1A1 (0.76) | KDM4EHSD17B10CYP3A4CYP2C9HPGD | |
| SCHEMBL4546626 | 0.76 | ALDH1A1 (0.74) | KDM4EHSD17B10CYP3A4CYP2C9HPGD | |
| SCHEMBL1459007 | 0.75 | ALDH1A1 (0.68) | KDM4EHSD17B10CYP3A4CYP2C9HPGD | |
| SCHEMBL5009465 | 0.75 | HTR1A (0.78) | KDM4EHSD17B10CYP3A4CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6136781-A | NOVEL CYCLIC PENTAPEPTIDE OR SALTS EFFECTIVE AS MEDICINES FOR PREVENTING AND CURING SEX HORMONE-DEPENDENT CANCERS, PROSTATOMEGALY, ENDOMETRIOSIS, HYSTEROMYOMA, PUBERTY PRECOX, AMENORRHEAL SYNDROMES, MULTIOCULAR OVARIAN SYNDROMES, ALSO | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-10-24 | — | — | US | disclosed |