Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 5/20 | 0.41 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.40 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6221826 | 0.88 | GRM5 (0.45) | VNN1ADORA2APARP1CHRNA7ERCC5 | |
| SCHEMBL6221038 | 0.86 | MAPT (0.45) | VNN1ADORA2AGRM5 | |
| SCHEMBL8198909 | 0.86 | POLB (0.45) | VNN1ADCY8ADCY1PARP1GRM5 | |
| SCHEMBL8198347 | 0.86 | TSHR (0.41) | ADCY8ADCY1CYP2C19PARP1GRM5 | |
| SCHEMBL8198559 | 0.84 | CYP3A4 (0.44) | VNN1ADCY8ADCY1CYP3A4PDE4B | |
| SCHEMBL6226517 | 0.83 | VNN1 (0.40) | VNN1CYP3A4CYP2C19ADORA2ACHRNA7 | |
| SCHEMBL8197231 | 0.83 | VNN1 (0.40) | VNN1ADORA2ACHRNA7ERCC5FEN1 | |
| SCHEMBL8196200 | 0.82 | MAPT (0.40) | VNN1CYP2C19ERCC5FEN1GRM5 | |
| SCHEMBL8198616 | 0.82 | ADORA1 (0.48) | VNN1CYP2C19ADORA2AGRM5 | |
| SCHEMBL6221993 | 0.81 | HPGD (0.40) | VNN1CHRNA7GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6136810-A | DRUGS AS ENZYME INHIBITORS OF PHOSPHODIESTERASE | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| EP-0885894-A1 | PYRIDO [2,3-D] PYRIMIDINE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |