Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.39 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.39 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | IDH2 | P48735 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8193874 | 0.87 | MEN1 (0.39) | MAPTRXFP1ALDH1A1DDR1GRM5 | |
| SCHEMBL6221826 | 0.84 | GRM5 (0.45) | VNN1ALDH1A1ERCC5FEN1GRM5 | |
| SCHEMBL6221038 | 0.83 | MAPT (0.45) | MAPTRXFP1VNN1ALDH1A1GRM5 | |
| SCHEMBL8185074 | 0.82 | VNN1 (0.41) | VNN1ERCC5FEN1GRM5CYP2C19 | |
| SCHEMBL8198322 | 0.81 | LMNA (0.44) | MAPTALDH1A1BDKRB1ERCC5FEN1 | |
| SCHEMBL8197231 | 0.81 | VNN1 (0.40) | VNN1ALDH1A1ERCC5FEN1GRM5 | |
| SCHEMBL6226517 | 0.81 | VNN1 (0.40) | MAPTRXFP1VNN1ERCC5FEN1 | |
| SCHEMBL8198616 | 0.80 | ADORA1 (0.48) | MAPTVNN1ALDH1A1GRM5LMNA | |
| SCHEMBL8193773 | 0.79 | ALDH1A1 (0.41) | MAPTRXFP1VNN1ALDH1A1GRM5 | |
| SCHEMBL6221993 | 0.79 | HPGD (0.40) | MAPTVNN1ALDH1A1GRM5SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6136810-A | DRUGS AS ENZYME INHIBITORS OF PHOSPHODIESTERASE | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| EP-0885894-A1 | PYRIDO [2,3-D] PYRIMIDINE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |