Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.30 |
| ▸ | PPOX | P50336 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8186058 | 0.92 | PPOX (0.31) | PPOX | |
| SCHEMBL8192987 | 0.83 | PGK1 (0.36) | KMT2A | |
| SCHEMBL8192289 | 0.82 | HSP90AA1 (0.36) | MEN1KMT2A | |
| SCHEMBL8189377 | 0.82 | MAPK1 (0.36) | MEN1PPOXKMT2A | |
| SCHEMBL8187343 | 0.76 | PGK1 (0.35) | — | |
| SCHEMBL8178803 | 0.76 | COMT (0.34) | MEN1KMT2A | |
| SCHEMBL8187079 | 0.76 | COMT (0.41) | MEN1KMT2A | |
| SCHEMBL8201364 | 0.75 | PPOX (0.36) | MEN1PPOXKMT2A | |
| SCHEMBL8192247 | 0.74 | PPOX (0.36) | PPOX | |
| SCHEMBL8553353 | 0.74 | MAPT (0.38) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6015774-A | Pyrazin-2-one derivatives, their use, and intermediates for their production | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2000-01-18 | — | — | US | disclosed |
| EP-0859765-A1 | PYRAZIN-2-ONE DERIVATIVES, THEIR USE, AND INTERMEDIATES FOR THEIR PRODUCTION | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 1998-08-26 | — | — | EP | disclosed |
| WO-1997011060-A1 | PYRAZIN-2-ONE DERIVATIVES, THEIR USE, AND INTERMEDIATES FOR THEIR PRODUCTION | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1997-03-27 | — | — | WO | disclosed |