Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPOX | P50336 | 2/20 | 0.36 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.34 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | GAK | O14976 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.33 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8192289 | 0.91 | HSP90AA1 (0.36) | BCAT2BCAT1RXFP1CYP1A2ALDH1A1 | |
| SCHEMBL8188528 | 0.85 | LMNA (0.44) | PPOXALDH1A1MAPTMAPK1 | |
| SCHEMBL8187343 | 0.85 | PGK1 (0.35) | ALDH1A1PKM | |
| SCHEMBL8201364 | 0.84 | PPOX (0.36) | PPOXALDH1A1MAPTMAPK1 | |
| SCHEMBL8189287 | 0.83 | COMT (0.40) | ALDH1A1PKMCOMT | |
| SCHEMBL8177457 | 0.83 | ALDH1A1 (0.33) | FGFR1FGFR2FGFR3ALDH1A1PKM | |
| SCHEMBL8186058 | 0.83 | PPOX (0.31) | PPOXALDH1A1PKM | |
| SCHEMBL8177599 | 0.82 | PPOX (0.35) | PPOXALDH1A1PKMMAPTPOLB | |
| SCHEMBL8189374 | 0.82 | PPOX (0.46) | PPOXALDH1A1PKMMAPTPOLB | |
| SCHEMBL8189134 | 0.81 | TDP1 (0.35) | CYP1A2ALDH1A1PKMMAPTCOMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6015774-A | Pyrazin-2-one derivatives, their use, and intermediates for their production | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2000-01-18 | — | — | US | disclosed |
| CN-1202159-A | Pyrazin-2-one derivatives, their use, and intermediates for their production | SUMITOMO CHEMICAL CO (JP) | 1998-12-16 | — | — | CN | disclosed |
| EP-0859765-A1 | PYRAZIN-2-ONE DERIVATIVES, THEIR USE, AND INTERMEDIATES FOR THEIR PRODUCTION | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 1998-08-26 | — | — | EP | disclosed |
| WO-1997011060-A1 | PYRAZIN-2-ONE DERIVATIVES, THEIR USE, AND INTERMEDIATES FOR THEIR PRODUCTION | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1997-03-27 | — | — | WO | disclosed |