Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 11/20 | 0.77 |
| ▸ | PIM2 | Q9P1W9 | 10/20 | 0.77 |
| ▸ | IGF1R | P08069 | 1/20 | 0.77 |
| ▸ | HPGD | P15428 | 4/20 | 0.67 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | MYC | P01106 | 1/20 | 0.60 |
| ▸ | MAX | P61244 | 1/20 | 0.60 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8186364 | 1.00 | PIM1 (0.77) | PIM1PIM2IGF1RHPGDCISD1 | |
| SCHEMBL2539569 | 0.87 | PIM1 (1.00) | PIM1PIM2IGF1RHPGDCISD1 | |
| SCHEMBL2539573 | 0.87 | PIM1 (1.00) | PIM1PIM2IGF1RHPGDCISD1 | |
| SCHEMBL2539566 | 0.87 | PIM1 (1.00) | PIM1PIM2IGF1RHPGDCISD1 | |
| SCHEMBL12107430 | 0.80 | HPGD (1.00) | PIM1PIM2IGF1RHPGDCISD1 | |
| SCHEMBL1250116 | 0.79 | PIM1 (0.69) | PIM1PIM2IGF1RHPGDCISD1 | |
| SCHEMBL1250117 | 0.79 | PIM1 (0.69) | PIM1PIM2IGF1RHPGDCISD1 | |
| SCHEMBL7974643 | 0.79 | MMP3 (0.75) | HPGDRAB9ANPC1MYCMAX | |
| SCHEMBL4049595 | 0.79 | MMP3 (0.75) | HPGDRAB9ANPC1MYCMAX | |
| SCHEMBL8186874 | 0.78 | MEN1 (0.57) | PIM1PIM2IGF1RHPGDCISD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018746-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |