Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.53 |
| ▸ | CDC7 | O00311 | 3/20 | 0.51 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | PI4KA | P42356 | 2/20 | 0.45 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.45 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.45 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | MGMT | P16455 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2938609 | 0.80 | PDPK1 (0.62) | PDPK1CDC7DBF4CDK2CDK1 | |
| SCHEMBL38657082 | 0.76 | PDPK1 (0.57) | PDPK1CDC7DBF4CDK2CDK1 | |
| SCHEMBL4397297 | 0.75 | PDPK1 (0.55) | PDPK1CDC7DBF4CDK2CDK1 | |
| SCHEMBL2938157 | 0.74 | CDC7 (0.59) | PDPK1CDC7DBF4CDK2TP53 | |
| SCHEMBL9621465 | 0.73 | PDPK1 (0.47) | PDPK1CDC7DBF4CDK2CDK1 | |
| SCHEMBL2940697 | 0.73 | PDPK1 (0.67) | PDPK1CDC7DBF4CDK2CDK1 | |
| SCHEMBL4496030 | 0.72 | CDC7 (0.60) | PDPK1CDC7DBF4CDK2CDK1 | |
| SCHEMBL17165605 | 0.71 | MKNK1 (0.52) | PDPK1CDC7DBF4TP53TSHR | |
| SCHEMBL528456 | 0.71 | CDC7 (0.50) | PDPK1CDC7DBF4CDK2CDK1 | |
| SCHEMBL3388864 | 0.70 | PDPK1 (0.68) | PDPK1CDC7DBF4CDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6086871-A | PROTHROMBIN MUTANT HAVING BINDING CAPACITY TO HIRUDIN, HEPARIN, AND ANTITHROMBIN; SPECIFIC REPLACEMENTS OR DELETIONS IN THEIR AMINO ACID SEQUENCES, AND AN ACTIVITY OF NO MORE THAN 0.25% OF THROMBIN; ANTICOAGULANT SIDE EFFECT REDUCTION | BAXTER AKTIENGESELLSCHAFT (AT) | 2000-07-11 | — | — | US | disclosed |