Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | CDC7 | O00311 | 3/20 | 0.46 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PI4KA | P42356 | 2/20 | 0.40 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.40 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9621704 | 0.80 | MAP3K7 (0.35) | DRD3 | |
| SCHEMBL38657082 | 0.79 | PDPK1 (0.57) | PDPK1CDC7DBF4CDK1CDK2 | |
| SCHEMBL2938609 | 0.74 | PDPK1 (0.62) | PDPK1CDC7DBF4CDK1CDK2 | |
| SCHEMBL29569289 | 0.74 | TSHR (0.51) | CDC7DBF4LMNATSHRTP53 | |
| SCHEMBL9621611 | 0.74 | TSHR (0.51) | CDC7DBF4LMNATSHRTP53 | |
| SCHEMBL8187698 | 0.73 | PDPK1 (0.53) | PDPK1CDC7DBF4CYP3A4CDK1 | |
| SCHEMBL4397297 | 0.70 | PDPK1 (0.55) | PDPK1CDC7DBF4CDK1CDK2 | |
| SCHEMBL2938157 | 0.69 | CDC7 (0.59) | PDPK1CDC7DBF4CDK2LMNA | |
| SCHEMBL4496030 | 0.67 | CDC7 (0.60) | PDPK1CDC7DBF4CYP3A4CDK1 | |
| SCHEMBL17165605 | 0.67 | MKNK1 (0.52) | PDPK1CDC7DBF4LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186454-B1 | 6-PURINYL N-(2-CHLOROETHYL) CARBAMATE AND THIOCARBAMATE, A PROCESS FOR THEIR PREPARATION AND USE THEREOF | SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu (CS) | 1992-04-08 | — | — | EP | claimed |
| US-4720497-A | 6-purinyl N-/2-chloroethyl/carbamate and thiocarbamate and process for the preparation thereof | SPOFA, SPOJENE PODNIKY PRO ZDRAVOTNICKOU VYROBU (CS) | 1988-01-19 | — | — | US | claimed |
| EP-0186454-A2 | 6-Purinyl N-(2-chloroethyl) carbamate and thiocarbamate, a process for their preparation and use thereof | SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu (CS) | 1986-07-02 | — | — | EP | claimed |
| JP-61186382-A | — | — | None | — | — | JP | disclosed |
| EP-0186454-B1 | 6-PURINYL N-(2-CHLOROETHYL) CARBAMATE AND THIOCARBAMATE, A PROCESS FOR THEIR PREPARATION AND USE THEREOF | SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu (CS) | 1992-04-08 | — | — | EP | disclosed |
| EP-0186454-B1 | 6-PURINYL N-(2-CHLOROETHYL) CARBAMATE AND THIOCARBAMATE, A PROCESS FOR THEIR PREPARATION AND USE THEREOF | SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu (CS) | 1992-04-08 | — | — | EP | disclosed |
| US-4720497-A | 6-purinyl N-/2-chloroethyl/carbamate and thiocarbamate and process for the preparation thereof | SPOFA, SPOJENE PODNIKY PRO ZDRAVOTNICKOU VYROBU (CS) | 1988-01-19 | — | — | US | disclosed |
| US-4720497-A | 6-purinyl N-/2-chloroethyl/carbamate and thiocarbamate and process for the preparation thereof | SPOFA, SPOJENE PODNIKY PRO ZDRAVOTNICKOU VYROBU (CS) | 1988-01-19 | — | — | US | disclosed |
| US-4720497-A | 6-purinyl N-/2-chloroethyl/carbamate and thiocarbamate and process for the preparation thereof | SPOFA, SPOJENE PODNIKY PRO ZDRAVOTNICKOU VYROBU (CS) | 1988-01-19 | — | — | US | disclosed |
| JP-S61186382-A | 6-PURINYL N-(2-CHLOROETHYL)CARBAMATE AND THIOCARBAMATE AND MANUFACTURE | SPOFA VEREINIGTE PHARMA WERKE | 1986-08-20 | — | — | JP | disclosed |
| EP-0186454-A2 | 6-Purinyl N-(2-chloroethyl) carbamate and thiocarbamate, a process for their preparation and use thereof | SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu (CS) | 1986-07-02 | — | — | EP | disclosed |
| EP-0186454-A2 | 6-Purinyl N-(2-chloroethyl) carbamate and thiocarbamate, a process for their preparation and use thereof | SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu (CS) | 1986-07-02 | — | — | EP | disclosed |
| EP-0186454-A2 | 6-Purinyl N-(2-chloroethyl) carbamate and thiocarbamate, a process for their preparation and use thereof | SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu (CS) | 1986-07-02 | — | — | EP | disclosed |