Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 3/20 | 0.47 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Menthol SCHEMBL27888021 | 0.79 | TRPM8 (0.62) | TRPM8TRPA1KMT2AMEN1ALDH1A1 | |
| Diphenylether SCHEMBL28381201 | 0.78 | TRPM8 (0.64) | TRPM8TRPA1TRPV1KMT2AKDM4E | |
| SCHEMBL2032746 | 0.77 | TRPV1 (0.50) | TRPM8TRPV1ALDH1A1HPGDKCNA5 | |
| SCHEMBL643462 | 0.76 | KMT2A (0.63) | KMT2AKDM4EMEN1RECQLALDH1A1 | |
| Menthol SCHEMBL28980170 | 0.76 | TRPA1 (0.60) | TRPM8TRPA1KMT2AMEN1ALDH1A1 | |
| Menthol SCHEMBL27673361 | 0.75 | TRPM8 (0.78) | TRPM8TRPA1TRPV1ALDH1A1KCNA5 | |
| Hydrochloric Acid SCHEMBL27525464 | 0.75 | KMT2A (0.61) | KMT2AKDM4EMEN1RECQLALDH1A1 | |
| Bromide SCHEMBL28850559 | 0.75 | KMT2A (0.61) | KMT2AKDM4EMEN1RECQLALDH1A1 | |
| Palmitic Acid SCHEMBL28857858 | 0.74 | TRPA1 (0.58) | TRPM8TRPA1KMT2AMEN1ALDH1A1 | |
| Dodecanoate SCHEMBL18247782 | 0.74 | TRPA1 (0.58) | TRPM8TRPA1KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6011001-A | Method of protein therapy by orally administering crosslinked protein crystals | VERTEX PHARMACEUTICALS, INC. (US) | 2000-01-04 | — | — | US | disclosed |
| US-6004768-A | Biosensors, extracorporeal devices and methods for detecting substances using crosslinked protein crystals | VERTEX PHARMACEUTICALS, INC. (US) | 1999-12-21 | — | — | US | disclosed |
| US-5976529-A | Methods of enzyme therapy by orally administering crosslinked enzyme crystals | VERTEX PHARMACEUTICALS, INC. (US) | 1999-11-02 | — | — | US | disclosed |
| US-5849296-A | Crosslinked protein crystals | VERTEX PHARMACEUTICALS, INC. (US) | 1998-12-15 | — | — | US | disclosed |
| US-5618710-A | RESISTANCE TO EXOGENOUS PROTEOLYSIS | VERTEX PHARMACEUTICALS, INC. (US) | 1997-04-08 | — | — | US | disclosed |