SCHEMBL818878

SCHEMBL818878

CC1=Cc2c(-c3cccc4ccccc34)cccc2C1[Hf](Cl)(Cl)(C1C(C)=Cc2c(-c3cccc4ccccc34)cccc21)[SiH](C)C

nearest known ligand 0.34

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.34
ENPP3 O14638 1/20 0.32
ENPP1 P22413 1/20 0.32
ALOX15 P16050 3/20 0.31
CA12 O43570 2/20 0.31
CA1 P00915 2/20 0.31
CA2 P00918 2/20 0.31
CA9 Q16790 2/20 0.31
NPC1 O15118 1/20 0.30
MAPT P10636 1/20 0.30
RAB9A P51151 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
ALDH1A1 P00352 1/20 0.30
CYP2A6 P11509 1/20 0.30
DHFR P00374 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL817965 0.91 NPC1 (0.33) NPC1MAPTRAB9ASMN1; SMN2
SCHEMBL8604997 0.88 KDM4E (0.32) KDM4E
SCHEMBL8602732 0.88 KDM4E (0.30) KDM4EENPP3ENPP1CA12CA1
SCHEMBL8604969 0.88 KDM4E (0.33) KDM4ECA12CA1CA2CA9
SCHEMBL1048785 0.86 KDM4E (0.32) KDM4EENPP3ENPP1CA12CA1
SCHEMBL2236542 0.85 HTR7 (0.31)
SCHEMBL8359951 0.85 ALOX15 (0.34) KDM4EENPP3ENPP1ALOX15NPC1
SCHEMBL818623 0.84 ALOX15 (0.30) ALOX15
SCHEMBL8458837 0.84
SCHEMBL8357846 0.84 KDM4E (0.34) KDM4ECA12CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015065784-A1 NOVEL ALUMINUM ALKYL WITH C5 CYCLIC AND PENDENT OLEFIN POLYMERIZATION CATALYST EXXONMOBIL CHEMICAL PATENTS INC. (US) 2015-05-07 WO claimed
US-20150119540-A1 Novel Aluminum Alkyl With C5 Cyclic and Pendent Olefin Polymerization Catalyst EXXONMOBIL CHEMICAL PATENTS INC. 2015-04-30 US claimed
EP-1799726-B1 TRIALKYLALUMINUM TREATED SUPPORTS EXXONMOBIL CHEM PATENTS INC (US) 2011-07-13 EP claimed
US-7741417-B2 Preparation of polymerization catalyst activators utilizing indole-modified silica supports EXXONMOBIL CHEMICAL PATENTS INC. (US) 2010-06-22 US claimed
US-7385015-B2 Trialkylaluminum treated supports EXXONMOBIL CHEMICAL PATENTS INC. (US) 2008-06-10 US claimed
EP-1799726-A1 TRIALKYLALUMINUM TREATED SUPPORTS Exxonmobil Chemical Patents Inc. (US) 2007-06-27 EP claimed
US-20070055028-A1 Preparation of polymerization catalyst activators utilizing indole-modified silica supports EXXONMOBIL CHEMICAL PATENTS INC. 2007-03-08 US claimed
WO-2006044058-A1 TRIALKYLALUMINUM TREATED SUPPORTS EXXONMOBIL CHEMICAL PATENTS INC. (US) 2006-04-27 WO claimed
US-20060079394-A1 Trialkylaluminum treated supports EXXONMOBIL CHEMICAL PATENTS INC. 2006-04-13 US claimed
US-20050148743-A1 polymerization catalyst systems comprising an ion-exchange layered silicate, an organoaluminum compound, and a heterocyclic compound EXXONMOBIL CHEMICAL PATENTS INC. 2005-07-07 US claimed
EP-2760958-B1 SYSTEMS, METHODS AND COMPOSITIONS FOR PRODUCTION OF TIE-LAYER ADHESIVES EQUISTAR CHEM LP (US) 2020-08-12 EP disclosed
US-10676547-B2 Aluminum alkyls with pendant olefins on clays EXXONMOBIL CHEMICAL PATENTS INC. (US) 2020-06-09 US disclosed
EP-2673315-B1 POLYETHYLENE FILMS EQUISTAR CHEM LP (US) 2019-03-20 EP disclosed
EP-2064248-B1 PREPARATION OF POLYMERIZATION CATALYST ACTIVATORS UTILIZING INDOLE-MODIFIED SILICA SUPPORTS EXXONMOBIL CHEMICAL PATENTS INC (US) 2018-10-10 EP disclosed
US-10059788-B2 Organoaluminum activators on clays EXXONMOBIL CHEMICAL PATENTS INC. (US) 2018-08-28 US disclosed
US-5990242-A Propylene/ethylene-α-olefin block copolymer and process for processing the same SUMITOMO CHEMICAL CO., LTD. (JP) 1999-11-23 US disclosed
US-5912373-A Process for converting the achiral meso form of an ansa-metallocene complex into the chiral racemic form BASF AKTIENGESELLSCHAFT (DE) 1999-06-15 US disclosed
US-5892081-A REACTING TIN METALLOCENE WITH TRANSITION METAL HALIDE OR ALKOXIDE BASF AKTIENGESELLSCHAFT (DE) 1999-04-06 US disclosed
US-5840950-A Process for converting the achiral meso form or the racemate of an ansa-metallocene complex or mixtures thereof into one of its enantiomers BASF AKTIENGESELLSCHAFT (DE) 1998-11-24 US disclosed
CN-1190399-A Process for converting achiral meso form or racemate of ansa-metallocene complex or mixtures thereof into one of its enantiomers BASF AG (DE) 1998-08-12 CN disclosed