Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.56 |
| ▸ | AHR | P35869 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PLK1 | P53350 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8871762 | 0.87 | KDM4E (0.70) | KDM4EAHRL3MBTL1KMT2AGAA | |
| SCHEMBL8786172 | 0.84 | ALDH1A1 (0.57) | KDM4EL3MBTL1PTGS2MEN1KMT2A | |
| SCHEMBL8201626 | 0.84 | L3MBTL1 (0.60) | KDM4EL3MBTL1MEN1KMT2AALDH1A1 | |
| SCHEMBL4593787 | 0.81 | KDM4E (0.70) | KDM4EAHRL3MBTL1PTGS2GAA | |
| SCHEMBL3646805 | 0.81 | ALDH1A1 (0.64) | KDM4EAHRMEN1KMT2AGAA | |
| SCHEMBL19661983 | 0.81 | KCNH2 (0.66) | KDM4EAHRL3MBTL1ALDH1A1MAPT | |
| SCHEMBL3640653 | 0.81 | KDM4E (0.49) | KDM4EAHRMEN1KMT2AGAA | |
| SCHEMBL10897719 | 0.80 | PTGS2 (0.59) | KDM4EAHRL3MBTL1PTGS2MEN1 | |
| SCHEMBL11740903 | 0.79 | ALDH1A1 (0.58) | KDM4EAHRL3MBTL1MEN1KMT2A | |
| SCHEMBL20893393 | 0.79 | PLK1 (0.56) | KDM4EAHRL3MBTL1PTGS2PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE36832-E | AN ANTICHOLESTEROL AGENT TREATING HYPERCHOLESTEROLEMIA | NIHON NOHYAKU CO., LTD (JP) | 2000-08-22 | — | — | US | disclosed |
| EP-0613894-B1 | N-Heteroaryl-N'-phenylurea derivatives, their production and use | NIHON NOHYAKU CO LTD (JP) | 1999-05-06 | — | — | EP | disclosed |
| US-5464863-A | Anticholesterol agents | NIHON NOHYAKU CO., LTD. (JP) | 1995-11-07 | — | — | US | disclosed |
| EP-0613894-A1 | N-Heteroaryl-N'-phenylurea derivatives, their production and use | NIHON NOHYAKU CO., LTD. (JP) | 1994-09-07 | — | — | EP | disclosed |