Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 4/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.46 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.46 |
| ▸ | MYLK | Q15746 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.41 |
| ▸ | ITGA2 | P17301 | 4/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CLK3 | P49761 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8446026 | 0.85 | ROCK2 (0.41) | MELKFLT3CAMK2GCAMK2DMYLK | |
| SCHEMBL8184272 | 0.84 | P2RX7 (0.38) | MEN1RAB9AKMT2A | |
| SCHEMBL6299458 | 0.78 | FLT3 (0.46) | MELKFLT3CAMK2GCAMK2DMYLK | |
| SCHEMBL6298392 | 0.78 | FLT3 (0.40) | MELKFLT3CAMK2GCAMK2DMYLK | |
| SCHEMBL8189151 | 0.77 | MELK (0.44) | MELKFLT3CAMK2GCAMK2DMYLK | |
| SCHEMBL7801344 | 0.73 | MELK (0.55) | MELKROCK2PRKG1ITGB3ITGA2B | |
| SCHEMBL6294917 | 0.72 | FLT3 (0.35) | MELKFLT3CAMK2GCAMK2DMYLK | |
| SCHEMBL6298345 | 0.70 | ROCK2 (0.61) | MELKROCK2PRKG1ITGB3ITGA2B | |
| SCHEMBL6717457 | 0.69 | MELK (0.52) | MELKFLT3ROCK2PRKG1ITGB3 | |
| SCHEMBL8185147 | 0.69 | MELK (0.57) | MELKFLT3CAMK2GCAMK2DMYLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6110934-A | Substituted benzamide derivatives and their use as anticonvulsants | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-08-29 | — | — | US | disclosed |
| EP-0906283-A1 | SUBSTITUTED BENZAMIDE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997048683-A1 | SUBSTITUTED BENZAMIDE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1997-12-24 | — | — | WO | disclosed |