Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARG | P13631 | 6/20 | 0.54 |
| ▸ | RARB | P10826 | 5/20 | 0.54 |
| ▸ | RARA | P10276 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 17/20 | 0.42 |
| ▸ | RXRB | P28702 | 11/20 | 0.42 |
| ▸ | RXRG | P48443 | 11/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8189493 | 1.00 | RARG (0.54) | RARGRARBRARAALDH1A1MAPT | |
| SCHEMBL7879831 | 0.86 | RARG (0.52) | RARGRARBRARARXRARXRB | |
| SCHEMBL7879827 | 0.86 | RARG (0.52) | RARGRARBRARARXRARXRB | |
| SCHEMBL7879841 | 0.83 | RARG (0.62) | RARGRARBRARAMEN1KMT2A | |
| SCHEMBL7879838 | 0.83 | RARG (0.62) | RARGRARBRARAMEN1KMT2A | |
| SCHEMBL7878427 | 0.82 | RARG (0.57) | RARGRARBRARAMEN1KMT2A | |
| SCHEMBL7878425 | 0.82 | RARG (0.57) | RARGRARBRARAMEN1KMT2A | |
| SCHEMBL12808522 | 0.81 | ALDH1A1 (0.56) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL6875751 | 0.79 | ALDH1A1 (0.51) | RARGRARBRARAALDH1A1MAPT | |
| SCHEMBL7876464 | 0.78 | CYP26A1 (0.47) | RARGRARBRARAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0997455-A1 | Restricted 9-cis retenoids | American Cyanamid Company (US) | 2000-05-03 | — | — | EP | disclosed |
| US-5968908-A | Restricted 9-cis retinoids | AMERICAN CYANAMID COMPANY (US) | 1999-10-19 | — | — | US | disclosed |
| EP-0718285-A2 | Restricted 9-cis-retinoids | American Cyanamid Company (US) | 1996-06-26 | — | — | EP | disclosed |