Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TUBB1 | Q9H4B7 | 6/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.33 |
| ▸ | TUBB | P07437 | 5/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7259993 | 0.79 | KDM4E (0.35) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL4266561 | 0.77 | ME2 (0.34) | KDM4EMEN1NPC1TP53MAPT | |
| SCHEMBL27646301 | 0.76 | KDM4E (0.30) | KDM4EALDH1A1 | |
| SCHEMBL585529 | 0.76 | CLK4 (0.39) | KDM4ENPC1ALDH1A1TP53MAPT | |
| SCHEMBL6804334 | 0.75 | CYP1A1 (0.33) | KDM4EALDH1A1CYP1A1CYP1B1CDK1 | |
| SCHEMBL7261530 | 0.74 | ALDH1A1 (0.35) | KDM4EMEN1NPC1ALDH1A1TP53 | |
| SCHEMBL584790 | 0.74 | HSD17B1 (0.37) | CDK1CCNB1PIK3CDSRCPIK3CA | |
| SCHEMBL499169 | 0.74 | PDE4A (0.44) | KDM4EMEN1NPC1ALDH1A1HPGD | |
| SCHEMBL28278669 | 0.73 | — | — | |
| SCHEMBL28299925 | 0.73 | QPCT (0.35) | ALDH1A1HPGDHSD17B10PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6087493-A | ENZYME IHIBITORS | REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2000-07-11 | — | — | US | disclosed |
| EP-0988037-A1 | PORPHYRIN COMPOUNDS AS TELOMERASE INHIBITORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998033503-A1 | PORPHYRIN COMPOUNDS AS TELOMERASE INHIBITORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1998-08-06 | — | — | WO | disclosed |