Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8191656 | 0.85 | GPR17 (0.36) | MDM2LMNAKDM4EALDH1A1MEN1 | |
| SCHEMBL469601 | 0.83 | MDM2 (0.51) | MDM2LMNAKDM4EALOX15ALDH1A1 | |
| SCHEMBL5411620 | 0.83 | MDM2 (0.42) | MDM2LMNAALOX15ALDH1A1MAPT | |
| SCHEMBL5393455 | 0.81 | LMNA (0.56) | LMNAKDM4EALOX15ALDH1A1MAPT | |
| SCHEMBL8540936 | 0.79 | NR1H2 (0.45) | MDM2LMNAKDM4EALDH1A1MAPT | |
| SCHEMBL8545119 | 0.78 | MDM2 (0.41) | MDM2LMNAALOX15ALDH1A1TP53 | |
| SCHEMBL8542139 | 0.77 | MDM2 (0.45) | MDM2LMNAALDH1A1MAPTGAA | |
| SCHEMBL8540675 | 0.77 | MDM2 (0.46) | MDM2LMNAKDM4EALOX15ALDH1A1 | |
| SCHEMBL8538965 | 0.77 | MDM2 (0.46) | MDM2LMNAKDM4EALDH1A1TP53 | |
| SCHEMBL8540513 | 0.77 | MDM2 (0.48) | MDM2LMNAKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100289-A | ADMINISTERING AN ANALGESIC AMOUNT OF EXCITATORY AMINO ACID ANTAGONIST TO MAMMAL | GLAXO WELLCOME SPA (IT) | 2000-08-08 | — | — | US | disclosed |
| US-5962496-A | CENTRAL NERVOUS SYSTEM DISORDERS | GLAXO WELLCOME SPA (IT) | 1999-10-05 | — | — | US | disclosed |
| US-5760059-A | ANTAGONISTS OF EXCITATORY AMINO ACIDS, TREATMENT OF NEURODEGENERATIVE DISEASES | GLAXO WELLCOME SPA (IT) | 1998-06-02 | — | — | US | disclosed |
| EP-0723541-A1 | INDOLE DERIVATIVES AS NMDA ANTAGONISTS | GLAXO WELLCOME S.p.A. (IT) | 1996-07-31 | — | — | EP | disclosed |
| WO-1995010517-A1 | INDOLE DERIVATIVES AS NMDA ANTAGONISTS | GLAXO WELLCOME S.P.A. (IT) | 1995-04-20 | — | — | WO | disclosed |