Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 5/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8190870 | 0.83 | MDM2 (0.42) | MDM2ALOX15MEN1KMT2ALMNA | |
| SCHEMBL14377351 | 0.80 | ALOX15 (0.54) | ALOX15MEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL12228528 | 0.78 | MDM2 (0.47) | MDM2ALOX15LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL16610189 | 0.75 | MDM2 (0.50) | MDM2ALOX15MEN1KMT2ALMNA | |
| SCHEMBL5411620 | 0.70 | MDM2 (0.42) | MDM2ALOX15LMNAL3MBTL1MAPT | |
| SCHEMBL19013032 | 0.70 | L3MBTL1 (0.51) | MDM2ALOX15L3MBTL1MAPTALDH1A1 | |
| SCHEMBL7506290 | 0.70 | LMNA (0.51) | MDM2ALOX15KMT2ALMNAL3MBTL1 | |
| SCHEMBL7512111 | 0.70 | LMNA (0.48) | MDM2ALOX15LMNAL3MBTL1MAPT | |
| SCHEMBL4337410 | 0.69 | ALOX15 (0.47) | ALOX15LMNAL3MBTL1NPSR1MAPT | |
| SCHEMBL8540705 | 0.69 | MDM2 (0.45) | MDM2MEN1KMT2ALMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9187441-B2 | p53-Mdm2 antagonists | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2015-11-17 | — | — | US | disclosed |
| US-9187441-B2 | p53-Mdm2 antagonists | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2015-11-17 | — | — | US | disclosed |
| WO-2012033525-A2 | P53-MDM2 ANTAGONISTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-03-15 | — | — | WO | disclosed |