Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.56 |
| ▸ | TET3 | O43151 | 2/20 | 0.56 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.56 |
| ▸ | OR51E2 | Q9H255 | 2/20 | 0.48 |
| ▸ | KDM4A | O75164 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL126063 | 1.00 | SMN1; SMN2 (0.60) | SMN1; SMN2TET2TET3TET1OR51E2 | |
| SCHEMBL5817385 | 1.00 | SMN1; SMN2 (0.60) | SMN1; SMN2TET2TET3TET1OR51E2 | |
| SCHEMBL22228591 | 0.97 | SMN1; SMN2 (0.57) | SMN1; SMN2TET2TET3TET1OR51E2 | |
| Pyruvate SCHEMBL16369836 | 0.90 | SMN1; SMN2 (0.50) | SMN1; SMN2TET2TET3TET1OR51E2 | |
| Glyoxylate SCHEMBL1130730 | 0.88 | SMN1; SMN2 (0.48) | SMN1; SMN2TET2TET3TET1OR51E2 | |
| SCHEMBL8470732 | 0.78 | SMN1; SMN2 (0.36) | SMN1; SMN2TET2TET3TET1OR51E2 | |
| Oxaloacetate SCHEMBL2048613 | 0.78 | SMN1; SMN2 (0.68) | SMN1; SMN2TET2TET3TET1OR51E2 | |
| Malic Acid SCHEMBL6863763 | 0.77 | SMN1; SMN2 (0.88) | SMN1; SMN2TET2TET3TET1OR51E2 | |
| Malic Acid SCHEMBL28319573 | 0.77 | SMN1; SMN2 (0.88) | SMN1; SMN2TET2TET3TET1OR51E2 | |
| SCHEMBL1533908 | 0.76 | OR51E2 (0.46) | SMN1; SMN2TET2TET3TET1OR51E2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0692539-B1 | Process for producing an optically active gamma-hydroxy-L-glutamic acid | KYOWA HAKKO KOGYO KK (JP) | 1999-09-22 | — | — | EP | claimed |
| US-5643769-A | Process for producing an optically active γ-hydroxy-L-glutamic acid | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-07-01 | — | — | US | claimed |
| EP-0692539-A2 | Process for producing an optically active gamma-hydroxy-L-glutamic acid | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-01-17 | — | — | EP | claimed |
| EP-0670371-A2 | Process for producing optically active 4-hydroxy-2-ketoglutaric acids | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-09-06 | — | — | EP | claimed |
| JP-11155572-A | — | — | None | — | — | JP | disclosed |
| CN-115305281-A | Biomarker for cerebral ischemia reperfusion injury and application of yin-nourishing brain-invigorating granules | 浙江中医药大学 | 2022-11-08 | — | — | CN | disclosed |
| EP-1045029-A2 | Process for producing optically active 4-hydroxy-2-ketoglutaric acids | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-10-18 | — | — | EP | disclosed |
| JP-H11155572-A | 4(R)-HYDROXY-2-KETOGLUTARIC ACID ALDOLASE AND DNA CODING FOR THE ENZYME | KYOWA HAKKO KOGYO CO LTD | 1999-06-15 | — | — | JP | disclosed |
| US-5607848-A | MIXING GLYOXYLIC ACID, PYRUVIC ACID, MICROORGANISM | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| EP-0670371-A2 | Process for producing optically active 4-hydroxy-2-ketoglutaric acids | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-09-06 | — | — | EP | disclosed |