SCHEMBL8192258

SCHEMBL8192258

C#CCN1C(=O)COc2cc(F)c(-c3ncc(C(F)(F)F)n(C)c3=O)cc21

nearest known ligand 0.51

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 3/20 0.33
CHRM5 P08912 1/20 0.31
CHRM3 P20309 1/20 0.31
BRD4 O60885 1/20 0.31
POLB P06746 1/20 0.30
EGFR P00533 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8187267 0.84 BRD4 (0.42) CHRM1BRD4
SCHEMBL5777245 0.84 BRD4 (0.34) CHRM1CHRM5CHRM3BRD4POLB
SCHEMBL12406710 0.83 CHRM1 (0.33) CHRM1CHRM5CHRM3BRD4EGFR
SCHEMBL6911403 0.79 SLC5A1 (0.33) CHRM1CHRM5CHRM3EGFR
SCHEMBL6719202 0.77 EGFR (0.34) EGFR
SCHEMBL6743760 0.77 PTAFR (0.32) CHRM1EGFR
SCHEMBL8570945 0.75 SLC5A1 (0.33) CHRM1EGFR
SCHEMBL39263 0.75 CHRM1 (0.35) CHRM1CHRM5CHRM3BRD4
SCHEMBL8177519 0.74 NR3C2 (0.41) POLB
SCHEMBL25359353 0.74 CHRM1 (0.35) CHRM1CHRM5CHRM3POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7973219-B2 Method for producing transgenic plants resistant to weed control compounds which disrupt the porphyrin pathways of plants SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-07-05 US disclosed
US-7973219-B2 Method for producing transgenic plants resistant to weed control compounds which disrupt the porphyrin pathways of plants SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-07-05 US disclosed
US-20100184597-A1 Method for producing transgenic plants resistant to weed control compounds which disrupt the porphyrin pathways of plants NAKAJIMA HIROKI 2010-07-22 US disclosed
US-20100184597-A1 Method for producing transgenic plants resistant to weed control compounds which disrupt the porphyrin pathways of plants NAKAJIMA HIROKI 2010-07-22 US disclosed
US-7485777-B2 Method for producing transgenic plants resistant to weed control compounds which disrupt the porphyrin pathways of plants SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-02-03 US disclosed
US-7485777-B2 Method for producing transgenic plants resistant to weed control compounds which disrupt the porphyrin pathways of plants SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-02-03 US disclosed
US-6015774-A Pyrazin-2-one derivatives, their use, and intermediates for their production SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-01-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100184597-A1 Method for producing transgenic plants resistant to weed control compounds which disrupt the porphyrin pathways of plants PPOX, HMBS, COX6B1 CHRM1 4271/4885CHRM5 3720/4885CHRM3 4208/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.