SCHEMBL39263

SCHEMBL39263

C#CCN1C(=O)COc2cc(F)c(-n3c(=O)cc(C(F)(F)F)n(C)c3=O)cc21

nearest known ligand 0.56

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 2/20 0.35
CHRM5 P08912 1/20 0.33
CHRM3 P20309 1/20 0.33
RORC P51449 1/20 0.31
BRD4 O60885 1/20 0.31
TP53 P04637 1/20 0.30
MAPT P10636 1/20 0.30
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9478242 0.90 KMO (0.32) CHRM1BRD4
SCHEMBL9032890 0.89 CHRM1 (0.32) CHRM1RORC
SCHEMBL15779803 0.87 CHRM1 (0.37) CHRM1CHRM5CHRM3BRD4
SCHEMBL9477928 0.86 CHRM1 (0.37) CHRM1CHRM5CHRM3
SCHEMBL9842340 0.85 CHRM1 (0.38) CHRM1CHRM5CHRM3RORCBRD4
SCHEMBL9478774 0.85 CHRM1 (0.38) CHRM1CHRM5CHRM3
SCHEMBL12981165 0.85 PIK3CG (0.36) BRD4TP53MAPTALDH1A1
SCHEMBL12188290 0.84 HTR1A (0.37) CHRM1
SCHEMBL29577537 0.83 CHRM1 (0.36) CHRM1CHRM5CHRM3
SCHEMBL38805 0.83 CHRM1 (0.36) CHRM1CHRM5CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4074174-A None JP disclosed
JP-3204865-A None JP disclosed
US-8748348-B2 3-(3,4-dihydro-2H-benzo [1,4]oxazin-6-yl)-1H-pyrimidin-2,4-dione compounds as herbicides BASF SE (DE) 2014-06-10 US disclosed
US-8481723-B2 3-(3,4-dihydro-2H-benzo [1,4]oxazin-6-yl)-1H-Pyrimidin-2,4-dione compounds as herbicides BASF SE (DE) 2013-07-09 US disclosed
US-8481723-B2 3-(3,4-dihydro-2H-benzo [1,4]oxazin-6-yl)-1H-Pyrimidin-2,4-dione compounds as herbicides BASF SE (DE) 2013-07-09 US disclosed
EP-2584896-A2 HERBICIDAL COMPOSITIONS BASF SE (DE) 2013-05-01 EP disclosed
US-20130102463-A1 Herbicidal Compositions BASF SE (DE) 2013-04-25 US disclosed
US-8293979-B2 Weed controller metabolism proteins, genes, thereof and use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-10-23 US disclosed
US-8293979-B2 Weed controller metabolism proteins, genes, thereof and use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-10-23 US disclosed
US-20120231952-A1 3-(3,4-dihydro-2H-benzo [1,4]oxazin-6-yl)-1H-Pyrimidin-2,4-dione compounds as herbicides BASF SE (DE) 2012-09-13 US disclosed
US-20100184597-A1 Method for producing transgenic plants resistant to weed control compounds which disrupt the porphyrin pathways of plants NAKAJIMA HIROKI 2010-07-22 US disclosed
US-7745699-B2 Weed controller metabolism proteins, genes thereof and use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-29 US disclosed
US-7745699-B2 Weed controller metabolism proteins, genes thereof and use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-29 US disclosed
US-7485777-B2 Method for producing transgenic plants resistant to weed control compounds which disrupt the porphyrin pathways of plants SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-02-03 US disclosed
US-7485777-B2 Method for producing transgenic plants resistant to weed control compounds which disrupt the porphyrin pathways of plants SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-02-03 US disclosed
US-5127935-A Halogen, phenyl and heterocycle substituents, agricultural use NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1992-07-07 US disclosed
JP-H0474174-A BENZOOXAZINYLURACIL DERIVATIVE, PREPARATION THEREOF AND HERBICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT SUMITOMO CHEM CO LTD 1992-03-09 JP disclosed
US-5084084-A Uracil and thiouracil derivatives NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1992-01-28 US disclosed
JP-H03204865-A URACIL DERIVATIVE AND HERBICIDE NISSAN CHEM IND LTD 1991-09-06 JP disclosed
EP-0420194-A2 Uracil derivatives and their production and use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1991-04-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100184597-A1 Method for producing transgenic plants resistant to weed control compounds which disrupt the porphyrin pathways of plants PPOX, HMBS, COX6B1 CHRM1 4271/4885CHRM5 3720/4885CHRM3 4208/4885
US-20130102463-A1 Herbicidal Compositions PPOX, PAOX, DDT CHRM1 3450/4885CHRM5 4136/4885CHRM3 3740/4885
US-20120231952-A1 3-(3,4-dihydro-2H-benzo [1,4]oxazin-6-yl)-1H-Pyrimidin-2,4-dione compounds as herbicides UNG, DDT, DPYD CHRM1 2955/4885CHRM5 3701/4885CHRM3 4049/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.