Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ESRRB | O95718 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2117787 | 0.76 | TSHR (0.48) | KMT2ASMN1; SMN2MAPTKDM4ETDP1 | |
| SCHEMBL9493113 | 0.73 | MAPT (0.41) | KMT2ASMN1; SMN2MAPTKDM4ETDP1 | |
| SCHEMBL580769 | 0.72 | TSHR (0.45) | KMT2ASMN1; SMN2MAPTKDM4ETDP1 | |
| SCHEMBL8408014 | 0.72 | CES1 (0.48) | KMT2ASMN1; SMN2MAPTKDM4ETDP1 | |
| SCHEMBL14073800 | 0.72 | MAPT (0.49) | KMT2ASMN1; SMN2MAPTKDM4ETDP1 | |
| SCHEMBL1537422 | 0.71 | MAPT (0.40) | KMT2ASMN1; SMN2MAPTKDM4ETDP1 | |
| SCHEMBL7748561 | 0.71 | KMT2A (0.64) | KMT2ASMN1; SMN2MAPTKDM4ETDP1 | |
| SCHEMBL9799560 | 0.70 | TSHR (0.63) | KMT2ASMN1; SMN2MAPTKDM4ETDP1 | |
| SCHEMBL535991 | 0.70 | MAOA (0.47) | KMT2ASMN1; SMN2MAPTKDM4ETDP1 | |
| SCHEMBL9053188 | 0.70 | MAPT (0.41) | KMT2ASMN1; SMN2MAPTKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6110903-A | INHIBITORS OF FRUCTOSE-1,6-BISPHOSPHATASE AT THE AMP SITE; ADMINISTERING TO TREAT DIABETES AND INHIBIT GLUCONEOGENESIS; 5-FLUORO-7-BROMO-1-ISOBUTYL-2-(2-PHOSPHONO-5-FURANYL) BENZIMIDAZOLE, FOR EXAMPLE | SANKYO COMPANY LTD. (JP) | 2000-08-29 | — | — | US | disclosed |