Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 4/20 | 0.42 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30592312 | 0.92 | EGFR (0.44) | MEN1KMT2AEGFRACKR3ALDH1A1 | |
| SCHEMBL5423494 | 0.78 | RAB9A (0.60) | KMT2AACKR3ALDH1A1LMNARAB9A | |
| SCHEMBL5431692 | 0.78 | RAB9A (0.60) | KMT2AACKR3ALDH1A1LMNARAB9A | |
| SCHEMBL6223208 | 0.76 | REN (0.42) | ALDH1A1RAB9ACYP2C19KDM4EHPGD | |
| SCHEMBL5419496 | 0.75 | NPC1 (0.56) | MEN1KMT2AEGFRALDH1A1RAB9A | |
| SCHEMBL5908898 | 0.74 | GLA (0.57) | MEN1KMT2AALDH1A1LMNARAB9A | |
| SCHEMBL5430953 | 0.74 | TSHR (0.54) | MEN1KMT2AALDH1A1NPC1KDM4E | |
| SCHEMBL8183855 | 0.73 | SMN1; SMN2 (0.54) | ALDH1A1LMNARAB9ANPC1CYP2C19 | |
| SCHEMBL846877 | 0.72 | EGFR (0.50) | KMT2AEGFRALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL400674 | 0.72 | EGFR (0.54) | EGFRALDH1A1LMNAKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6136810-A | DRUGS AS ENZYME INHIBITORS OF PHOSPHODIESTERASE | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| EP-0885894-A1 | PYRIDO [2,3-D] PYRIMIDINE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |
| CN-1202171-A | Pyrido [2,3-d] pyrimidine derivatives and medicinal compositions thereof | YAMANOUCHI PHARMA CO LTD (JP) | 1998-12-16 | — | — | CN | disclosed |