Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CD38 | P28907 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8193693 | 0.86 | REN (0.37) | RENPDE4BPDE4DALDH1A1POLB | |
| SCHEMBL8184257 | 0.78 | ALDH1A1 (0.47) | PDE4BPDE4DRAB9AALDH1A1CNR1 | |
| SCHEMBL8694919 | 0.77 | ALDH1A1 (0.48) | PDE4BPDE4DRAB9AALDH1A1KDM4E | |
| SCHEMBL11484236 | 0.76 | ACLY (0.49) | RENRAB9AALDH1A1POLBKDM4E | |
| SCHEMBL8193604 | 0.76 | MEN1 (0.42) | RAB9AALDH1A1CYP2C19KDM4EADORA2A | |
| SCHEMBL11080662 | 0.74 | KDM4E (0.40) | RAB9AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL27822171 | 0.73 | MEN1 (0.50) | RAB9AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL30637698 | 0.69 | CNR1 (0.39) | ALDH1A1POLBCNR1CNR2CYP2C19 | |
| SCHEMBL6644500 | 0.68 | CHRM3 (0.44) | PDE4BPDE4DRAB9AALDH1A1CNR1 | |
| SCHEMBL30592312 | 0.67 | EGFR (0.44) | ALDH1A1POLBKDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1225173-B1 | NAPHTHYRIDINE DERIVATIVES | ASTELLAS PHARMA INC (JP) | 2005-09-28 | — | — | EP | disclosed |
| US-6740662-B1 | HAVING 2-OXO-1,2-DIHYDRO- FUNCTIONALITY; PHOSPHODIESTERASE INHIBITORS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2004-05-25 | — | — | US | disclosed |
| EP-1225173-A1 | NAPHTHYRIDINE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2002-07-24 | — | — | EP | disclosed |
| US-6136810-A | DRUGS AS ENZYME INHIBITORS OF PHOSPHODIESTERASE | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| EP-0885894-A1 | PYRIDO [2,3-D] PYRIMIDINE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |
| CN-1202171-A | Pyrido [2,3-d] pyrimidine derivatives and medicinal compositions thereof | YAMANOUCHI PHARMA CO LTD (JP) | 1998-12-16 | — | — | CN | disclosed |