Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 12/20 | 0.79 |
| ▸ | NOS3 | P29474 | 11/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 6/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8060969 | 0.88 | NOS2 (1.00) | NOS2NOS3USP2NOS1PLK4 | |
| Iodide SCHEMBL8099764 | 0.86 | NOS2 (0.96) | NOS2NOS3USP2NOS1PLK4 | |
| SCHEMBL208564 | 0.69 | USP2 (0.50) | NOS2USP2PLK4CHEK1AURKA | |
| SCHEMBL17225453 | 0.66 | USP2 (0.50) | NOS2USP2PLK4CHEK1AURKA | |
| SCHEMBL22995934 | 0.64 | NOS2 (0.59) | NOS2NOS3USP2PLK4CHEK1 | |
| SCHEMBL1870494 | 0.64 | NOS2 (0.60) | NOS2NOS3USP2PLK4CHEK1 | |
| SCHEMBL14172813 | 0.63 | ALDH1A1 (0.51) | NOS2USP2CDK7CDK9CYP19A1 | |
| SCHEMBL8057615 | 0.63 | NOS2 (1.00) | NOS2NOS3NOS1ADRA2AADRA2B | |
| SCHEMBL153954 | 0.63 | USP2 (0.47) | NOS2USP2PLK4CHEK1AURKA | |
| SCHEMBL14434164 | 0.63 | USP2 (0.47) | NOS2USP2PLK4CHEK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000064904-A1 | 5,7-BICYCLIC AMIDINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | ASTRAZENECA AB (SE) | 2000-11-02 | — | — | WO | claimed |
| WO-2000064904-A1 | 5,7-BICYCLIC AMIDINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | ASTRAZENECA AB (SE) | 2000-11-02 | — | — | WO | disclosed |