Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 3/20 | 0.60 |
| ▸ | MAOA | P21397 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | LTK | P29376 | 1/20 | 0.37 |
| ▸ | GRK5 | P34947 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8060969 | 0.75 | NOS2 (1.00) | NOS2ALDH1A1PLK4CHEK1AURKA | |
| SCHEMBL8104298 | 0.75 | NOS2 (0.55) | NOS2PLK4CHEK1AURKADAPK3 | |
| SCHEMBL12158615 | 0.74 | NOS2 (0.50) | NOS2ALDH1A1PLK4CHEK1AURKA | |
| Iodide SCHEMBL8099764 | 0.73 | NOS2 (0.96) | NOS2PLK4CHEK1AURKADAPK3 | |
| SCHEMBL9216129 | 0.72 | NOS2 (0.51) | NOS2PLK4CHEK1AURKADAPK3 | |
| SCHEMBL17807492 | 0.69 | NOS2 (0.53) | NOS2ALDH1A1PLK4CHEK1AURKA | |
| SCHEMBL3307465 | 0.69 | NOS2 (0.61) | NOS2MAOAKDM4EMAPTALDH1A1 | |
| SCHEMBL15267114 | 0.69 | NOS2 (0.47) | NOS2KDM4EALDH1A1PLK4CHEK1 | |
| SCHEMBL14498864 | 0.67 | NOS2 (0.41) | NOS2MAPTPLK4CHEK1AURKA | |
| SCHEMBL3872610 | 0.67 | NOS2 (0.50) | NOS2PLK4CHEK1AURKADAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250059209-A1 | THERAPEUTIC AGENTS AND USES THEREOF | ANKH LIFE SCIENCES LIMITED (IE) | 2025-02-20 | — | — | US | disclosed |
| US-12129265-B2 | Therapeutic agents and uses thereof | ANKH LIFE SCIENCES LIMITED (IE) | 2024-10-29 | — | — | US | disclosed |
| EP-4185288-A1 | THERAPEUTIC AGENTS AND USES THEREOF | Ankh Life Sciences Limited (IE) | 2023-05-31 | — | — | EP | disclosed |
| CN-115916195-A | Therapeutic agents and uses thereof | 安科生命科学有限公司 | 2023-04-04 | — | — | CN | disclosed |
| US-20220033417-A1 | THERAPEUTIC AGENTS AND USES THEREOF | ANKH LIFE SCIENCES LIMITED (IE) | 2022-02-03 | — | — | US | disclosed |
| US-20220033417-A1 | THERAPEUTIC AGENTS AND USES THEREOF | ANKH LIFE SCIENCES LIMITED (IE) | 2022-02-03 | — | — | US | disclosed |
| WO-2022019892-A1 | THERAPEUTIC AGENTS AND USES THEREOF | ANKH LIFE SCIENCES LIMITED (IE) | 2022-01-27 | — | — | WO | disclosed |
| US-7947689-B2 | Substituted pyrazolo[1,5-a]pyrimidines as metabotropic glutamate receptor modulators | MERZ PHARMA GMBH & CO. KGAA (DE) | 2011-05-24 | — | — | US | disclosed |
| US-7947689-B2 | Substituted pyrazolo[1,5-a]pyrimidines as metabotropic glutamate receptor modulators | MERZ PHARMA GMBH & CO. KGAA (DE) | 2011-05-24 | — | — | US | disclosed |
| US-7947689-B2 | Substituted pyrazolo[1,5-a]pyrimidines as metabotropic glutamate receptor modulators | MERZ PHARMA GMBH & CO. KGAA (DE) | 2011-05-24 | — | — | US | disclosed |
| US-20080039476-A1 | Pyrazolopyrimidines, a process for their preparation and their use as medicine | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-02-14 | — | — | US | disclosed |
| WO-2008015270-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-02-07 | — | — | WO | disclosed |
| WO-2008015270-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-02-07 | — | — | WO | disclosed |
| US-5036066-A | Muscle relaxants, anxiolytic agents, anticonvulsants | HOFFMANN-LA ROCHE INC. (US) | 1991-07-30 | — | — | US | disclosed |
| EP-0183994-B1 | TRICYCLIC PYRIDONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1990-03-21 | — | — | EP | disclosed |
| US-4889848-A | 4-OXO-4H-BENZO(A)QUINOLIZINES; MUSCLE RELAXANTS; SEDATIVES; ANTICONVULSANTS; ANXIOLYTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1989-12-26 | — | — | US | disclosed |
| US-4839365-A | Thienopyridine derivatives useful in treating gastric ulcers | SHINOGI & CO., LTD. (JP) | 1989-06-13 | — | — | US | disclosed |
| EP-0292051-A2 | Thienopyridine derivatives | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1988-11-23 | — | — | EP | disclosed |
| US-4735940-A | Tricyclic pyridine derivatives and pharmaceutical compositions | HOFFMANN-LA ROCHE INC. (US) | 1988-04-05 | — | — | US | disclosed |
| EP-0183994-A1 | Tricyclic pyridone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1986-06-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250059209-A1 | THERAPEUTIC AGENTS AND USES THEREOF | MCL1, RNASE1, HNMT | NOS2 3574/4885MAOA 115/4885KDM4E 978/4885 |
| US-12129265-B2 | Therapeutic agents and uses thereof | MCL1, BCL9, RNASE1 | NOS2 3668/4885MAOA 74/4885KDM4E 1224/4885 |
| US-20080039476-A1 | Pyrazolopyrimidines, a process for their preparation and their use as medicine | GRM5, GRM3, GRM1 | NOS2 2895/4885MAOA 2093/4885KDM4E 1834/4885 |
| US-20220033417-A1 | THERAPEUTIC AGENTS AND USES THEREOF | MCL1, BCL9, RNASE1 | NOS2 3668/4885MAOA 74/4885KDM4E 1224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.