Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 12/20 | 0.49 |
| ▸ | NPC1 | O15118 | 9/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3871228 | 0.77 | MAPT (0.54) | MAPTRAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL6838461 | 0.77 | MAPT (0.54) | MAPTRAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL3699546 | 0.77 | MAPT (0.64) | MAPTRAB9ANPC1SMN1; SMN2HPGD | |
| Hydrochloric Acid SCHEMBL6989276 | 0.75 | MAPT (0.53) | MAPTRAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL20805209 | 0.72 | SMN1; SMN2 (0.61) | MAPTRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL10816647 | 0.72 | RAB9A (0.71) | MAPTRAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL1691061 | 0.72 | MAPT (0.68) | MAPTRAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL28292387 | 0.71 | SMN1; SMN2 (0.64) | MAPTRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL22904396 | 0.71 | MAPT (0.56) | MAPTRAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL48394 | 0.71 | MAPT (0.66) | MAPTRAB9ANPC1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6040289-A | ACTIVE DRUG TREATING OBESITY | DR. KARL THOMAE GMBH (DE) | 2000-03-21 | — | — | US | disclosed |