Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.55 |
| ▸ | HTR2A | P28223 | 3/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 7/20 | 0.50 |
| ▸ | CNR2 | P34972 | 5/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CASR | P41180 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4261942 | 0.82 | RIPK1 (0.47) | HRH1HTR2AMTNR1AMTNR1BKCNH2 | |
| SCHEMBL6104432 | 0.78 | GRIN1 (0.45) | HRH1HTR2AMTNR1AMTNR1BCYP3A4 | |
| SCHEMBL5543392 | 0.76 | HTR2A (0.44) | HRH1HTR2AMTNR1AMTNR1BKCNH2 | |
| SCHEMBL11796932 | 0.75 | KCNH2 (0.76) | HRH1HTR2AMTNR1AMTNR1BCNR1 | |
| SCHEMBL9052651 | 0.73 | MTOR (0.59) | CYP3A4LMNAALDH1A1ALOX15 | |
| Hydrochloric Acid SCHEMBL11794831 | 0.73 | KCNH2 (0.73) | HRH1HTR2AMTNR1AMTNR1BCNR1 | |
| SCHEMBL7283622 | 0.71 | HRH1 (0.61) | HRH1HTR2AMTNR1AMTNR1BCNR1 | |
| SCHEMBL21506455 | 0.71 | HRH1 (0.61) | HRH1HTR2AMTNR1AMTNR1BCNR1 | |
| SCHEMBL3638413 | 0.71 | HTR2A (1.00) | HRH1HTR2AMTNR1AMTNR1BCNR1 | |
| SCHEMBL5180043 | 0.71 | HRH1 (0.50) | HRH1HTR2AMTNR1AMTNR1BCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6040289-A | ACTIVE DRUG TREATING OBESITY | DR. KARL THOMAE GMBH (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5962530-A | NEUROPEPTIDE Y ANTAGONIST | DR. KARL THOMAE GMBH (DE) | 1999-10-05 | — | — | US | disclosed |
| EP-0441226-A1 | (cyanomethyl)pyridines useful as PAF antagonists | J. URIACH & CIA. S.A. (ES) | 1991-08-14 | — | — | EP | disclosed |