Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 12/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.39 |
| ▸ | PDE2A | O00408 | 2/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16799727 | 0.84 | MAP4K4 (0.49) | — | |
| SCHEMBL8199221 | 0.81 | SMPD3 (0.39) | PDE10APDE4DMAPK8 | |
| SCHEMBL4778875 | 0.80 | HRH3 (0.37) | PDE10APDE4D | |
| SCHEMBL1772389 | 0.78 | CASP1 (0.43) | — | |
| SCHEMBL8194170 | 0.78 | MAPT (0.48) | — | |
| SCHEMBL2067822 | 0.77 | MAPT (0.36) | PDE4D | |
| SCHEMBL743397 | 0.77 | MAPT (0.40) | — | |
| SCHEMBL8199180 | 0.77 | ALDH1A1 (0.46) | PDE10ALRRK2 | |
| SCHEMBL27471254 | 0.76 | GAA (0.46) | — | |
| SCHEMBL182711 | 0.76 | PLD1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000023444-A1 | 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-04-27 | — | — | WO | claimed |
| WO-2000023444-A1 | 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-04-27 | — | — | WO | disclosed |