Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 13/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.40 |
| ▸ | HPGD | P15428 | 7/20 | 0.40 |
| ▸ | TSHR | P16473 | 6/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 3/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3417957 | 0.78 | ALDH1A1 (0.47) | HSD17B10ALDH1A1HPGDTSHRUSP2 | |
| SCHEMBL4772450 | 0.75 | CNR2 (0.37) | HSD17B10ALDH1A1HPGDTSHRCYP2C19 | |
| SCHEMBL8206759 | 0.75 | ALDH1A1 (0.44) | HSD17B10ALDH1A1HPGDTSHRHIF1A | |
| SCHEMBL4774184 | 0.74 | OPRL1 (0.47) | OPRD1SMN1; SMN2 | |
| SCHEMBL2067822 | 0.72 | MAPT (0.36) | ALDH1A1TSHRSMN1; SMN2CYP1A2 | |
| SCHEMBL743397 | 0.72 | MAPT (0.40) | ALDH1A1TSHRSMN1; SMN2MAPK1CYP1A2 | |
| SCHEMBL8193762 | 0.72 | OPRM1 (0.43) | CYP2D6CYP3A4OPRD1CYP1A2 | |
| SCHEMBL932525 | 0.72 | HRH4 (0.45) | ALDH1A1CYP1A2HRH3 | |
| SCHEMBL28228988 | 0.71 | RET (0.48) | HSD17B10ALDH1A1HPGDTSHRCYP2C19 | |
| SCHEMBL8192616 | 0.70 | ADK (0.38) | ALDH1A1MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000023444-A1 | 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-04-27 | — | — | WO | claimed |
| WO-2000023444-A1 | 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-04-27 | — | — | WO | disclosed |