Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.44 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13343607 | 0.86 | KDM4E (0.46) | TOP2ATOP2BMAPTRXFP1GAA | |
| SCHEMBL31153423 | 0.86 | KDM4E (0.46) | TOP2ATOP2BMAPTRXFP1GAA | |
| SCHEMBL8197422 | 0.82 | TOP2A (0.44) | TOP2ATOP2BMAPTTNKSTNKS2 | |
| SCHEMBL8187460 | 0.79 | TOP2A (0.59) | TOP2ATOP2BMAPTTNKSTNKS2 | |
| SCHEMBL1307660 | 0.78 | NPSR1 (0.52) | TOP2ATOP2BMAPTRXFP1GAA | |
| SCHEMBL31153540 | 0.75 | ALDH1A1 (0.52) | MAPTGAAKDM4EHPGDHTT | |
| SCHEMBL165225 | 0.75 | ALDH1A1 (0.52) | MAPTGAAKDM4EHPGDHTT | |
| SCHEMBL13343587 | 0.75 | RXFP1 (0.56) | MAPTRXFP1GAANPSR1TUBB4A | |
| SCHEMBL3226572 | 0.74 | TYMS (0.63) | MAPTGAANPSR1TNKSCYP1A1 | |
| SCHEMBL1029334 | 0.74 | TYMS (0.63) | MAPTRXFP1GAANPSR1TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063668-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2008-05-29 | — | — | WO | disclosed |