Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.49 |
| ▸ | TUBB | P07437 | 1/20 | 0.49 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.49 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.49 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.49 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.49 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.49 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.49 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.49 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.49 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.49 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.49 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.49 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.49 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13343587 | 0.83 | RXFP1 (0.56) | NPSR1GAAMAPTRXFP1TUBB4A | |
| SCHEMBL1308852 | 0.82 | KDM4E (0.53) | NPSR1MAPTTUBB4ATUBBTUBA3C | |
| SCHEMBL17141642 | 0.80 | NPSR1 (0.50) | NPSR1GAAMAPTRXFP1TUBB4A | |
| SCHEMBL8196880 | 0.78 | TOP2A (0.44) | NPSR1GAAMAPTRXFP1TUBB4A | |
| SCHEMBL31317513 | 0.77 | TOP2A (0.54) | NPSR1GAAMAPTRXFP1TUBB4A | |
| SCHEMBL8197895 | 0.77 | ALDH1A1 (0.62) | NPSR1GAAMAPTRXFP1TUBB4A | |
| SCHEMBL30208243 | 0.77 | ALDH1A1 (0.62) | NPSR1GAAMAPTRXFP1TUBB4A | |
| SCHEMBL3115005 | 0.76 | TYMS (0.72) | NPSR1GAAMAPTRXFP1TUBB4A | |
| SCHEMBL29900526 | 0.76 | TYMS (0.72) | NPSR1GAAMAPTRXFP1TUBB4A | |
| SCHEMBL3424900 | 0.73 | TUBB4A (0.55) | NPSR1GAAMAPTRXFP1TUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053441-B2 | Pyrazolylquinazolinones as potassium channel openers | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-11-08 | — | — | US | disclosed |
| US-8053441-B2 | Pyrazolylquinazolinones as potassium channel openers | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-11-08 | — | — | US | disclosed |
| US-8053441-B2 | Pyrazolylquinazolinones as potassium channel openers | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-11-08 | — | — | US | disclosed |
| EP-1989197-A1 | PYRAZOLYLQUINAZOLINONES AS POTASSIUM CHANNEL OPENERS | Janssen Pharmaceutica, N.V. (BE) | 2008-11-12 | — | — | EP | disclosed |
| WO-2007098386-A1 | PYRAZOLYLQUINAZOLINONES AS POTASSIUM CHANNEL OPENERS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-08-30 | — | — | WO | disclosed |
| WO-2007098386-A1 | PYRAZOLYLQUINAZOLINONES AS POTASSIUM CHANNEL OPENERS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-08-30 | — | — | WO | disclosed |
| US-20070197566-A1 | NOVEL PYRAZOLYLQUINAZOLINONES AS POTASSIUM CHANNEL OPENERS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-08-23 | — | — | US | disclosed |
| US-20070197566-A1 | NOVEL PYRAZOLYLQUINAZOLINONES AS POTASSIUM CHANNEL OPENERS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-08-23 | — | — | US | disclosed |
| US-20070197566-A1 | NOVEL PYRAZOLYLQUINAZOLINONES AS POTASSIUM CHANNEL OPENERS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197566-A1 | NOVEL PYRAZOLYLQUINAZOLINONES AS POTASSIUM CHANNEL OPENERS | KCNJ2, KCNQ1, KCNN3 | NPSR1 1101/4885GAA 2922/4885MAPT 1145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.