Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 8/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | PGR | P06401 | 2/20 | 0.43 |
| ▸ | AR | P10275 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7081603 | 0.91 | NR3C1 (0.77) | NR3C1CYP3A4PGRARUSP2 | |
| SCHEMBL7905929 | 0.91 | NR3C1 (0.77) | NR3C1CYP3A4PGRARUSP2 | |
| SCHEMBL8204066 | 0.88 | NR3C1 (0.61) | NR3C1CYP3A4PGRARUSP2 | |
| SCHEMBL6329468 | 0.88 | NR3C1 (0.65) | NR3C1CYP3A4PGRARLMNA | |
| SCHEMBL8204287 | 0.87 | NR3C1 (0.74) | NR3C1CYP3A4PGRARUSP2 | |
| SCHEMBL8204887 | 0.87 | NR3C1 (0.64) | NR3C1CYP3A4PGRARUSP2 | |
| SCHEMBL8197395 | 0.86 | NR3C1 (0.77) | NR3C1CYP3A4PGRARLMNA | |
| Rofleponide SCHEMBL23803954 | 0.86 | NR3C1 (0.68) | NR3C1CYP3A4PGRARLMNA | |
| Rofleponide SCHEMBL5506220 | 0.86 | NR3C1 (0.68) | NR3C1CYP3A4PGRARLMNA | |
| Rofleponide SCHEMBL7196822 | 0.86 | NR3C1 (0.68) | NR3C1CYP3A4PGRARLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876393-B1 | 21-(2-OXO-TETRAHYDROFURAN)-THIO PREGNANE DERIVATIVES, A PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LTD (GB) | 2000-07-05 | — | — | EP | claimed |
| US-6013244-A | AS ANTI-INFLAMMATORY OR ANTI-ALLERGIC AGENTS | GLAXO WELLCOME INC. (US) | 2000-01-11 | — | — | US | claimed |
| EP-0876393-B1 | 21-(2-OXO-TETRAHYDROFURAN)-THIO PREGNANE DERIVATIVES, A PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LTD (GB) | 2000-07-05 | — | — | EP | disclosed |
| US-6013244-A | AS ANTI-INFLAMMATORY OR ANTI-ALLERGIC AGENTS | GLAXO WELLCOME INC. (US) | 2000-01-11 | — | — | US | disclosed |